Axial Spondyloarthropathies in the Western Cape

 

Show simple item record

dc.contributor.advisor Hodkinson, Bridget
dc.contributor.advisor Gould Trevor
dc.contributor.author Smith, Robert
dc.date.accessioned 2020-02-14T09:30:37Z
dc.date.available 2020-02-14T09:30:37Z
dc.date.issued 2019
dc.identifier.citation Smith, R. 2019. Axial Spondyloarthropathies in the Western Cape. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/31120
dc.description.abstract Impaired Health-Related Quality of Life and Work Productivity amongst South African patients with Axial Spondyloarthritis. Background: No studies have investigated health-related quality of life (HRQoL) or work productivity in patients with axial spondyloarthritides (axSpA) living in sub-Saharan Africa. Methods: This cross-sectional study of adults with axSpA collated demographic particulars and patient questionnaires: Bath Ankylosing Spondylitis Disease Activity Index (BASDAI); Bath Ankylosing Spondylitis Functional Index (BASFI); Bath Ankylosing Spondylitis Global Score (BASG); Medical Short Form (SF)-36; and Work Productivity and Activity Impairment Questionnaire: Specific Health Problem (WPAI:SHP). Results: Of 36 patients, the mean (SD) age was 40.3 (13.3) years and mean (SD) diagnostic delay was 8.7 (8.4) years. Most patients were male (80.6%) and of mixed racial ancestry (69.4%). Most (66.7%) patients were smokers and only 5 (13.9%) patients received tumor necrosis factor inhibitor (TNFi) therapy. The mean (SD) BASDAI was 5.3 (2.1), and 72.2% had a BASDAI ≥ 4. Patients with a high BASDAI (i.e. BASDAI ≥ 4) had higher BASG scores (p=0.003), higher WPAI:SHP activity impairment scores (p=0.003), and poorer SF-36 scores, particularly in the role-physical, bodily pain, and social functioning domains (p=0.0001, 0.001 and 0.02 respectively). Activity impairment according to the WPAI:SPH was 57.4%, with the BASDAI and activity impairment correlating closely (p=0.006). The SF-36 scores were low in physical (particularly role-physical, bodily pain, and general health) and mental (notably vitality and role emotional) domains. 6 Conclusion: This study describes a cohort of South African patients with axSpA who have poor prognostic features including diagnostic delay and cigarette smoking. Active disease, impaired function, poor physical- and mental HRQoL, and work disability are unmet needs.
dc.subject medicine
dc.title Axial Spondyloarthropathies in the Western Cape
dc.type Thesis / Dissertation
dc.date.updated 2020-02-14T09:30:24Z
dc.language.rfc3066 eng
dc.publisher.faculty Faculty of Health Sciences
dc.publisher.department Department of Medicine
dc.type.qualificationlevel Masters
dc.type.qualificationname MMed


Files in this item

This item appears in the following Collection(s)

Show simple item record