Where have all the susceptible gonococci gone? A historical review of changes in MIC distribution over the past 75 years

 

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dc.contributor.author Kenyon, Chris
dc.contributor.author Laumen, Jolein
dc.contributor.author Van Den Bossche, Dorien
dc.contributor.author Van Dijck, Christophe
dc.date.accessioned 2020-01-14T06:52:15Z
dc.date.available 2020-01-14T06:52:15Z
dc.date.issued 2019-12-27
dc.identifier.citation BMC Infectious Diseases. 2019 Dec 27;19(1):1085
dc.identifier.uri https://doi.org/10.1186/s12879-019-4712-x
dc.identifier.uri http://hdl.handle.net/11427/30723
dc.description.abstract Abstract Background Does the emergence of antimicrobial resistance in Neisseria gonorrhoeae include the erasure of highly susceptible strains or does it merely involve a stretching of the MIC distribution? If it was the former this would be important to know as it would increase the probability that the loss of susceptibility is irreversible. Methods We conducted a historical analysis based on a literature review of changes of N. gonorrhoeae MIC distribution over the past 75 years for 3 antimicrobials (benzylpenicillin, ceftriaxone and azithromycin) in five countries (Denmark, Japan, South Africa, the United Kingdom and the United States). Results Changes in MIC distribution were most marked for benzylpenicillin and showed evidence of a right shifting of MIC distribution that was associated with a reduction/elimination of susceptible strains in all countries. In the case of ceftriaxone and azithromycin, where only more recent data was available, right shifting was also found in all countries but the extent of right shifting varied and the evidence for the elimination of susceptible strains was more mixed. Conclusions The finding of right shifting of MIC distribution combined with reduction/elimination of susceptible strains is of concern since it suggests that this shifting may not be reversible. Since excess antimicrobial consumption is likely to be responsible for this right shifting, this insight provides additional impetus to promote antimicrobial stewardship.
dc.subject Neisseria gonorrhoeae
dc.subject Gonococcus
dc.subject Antimicrobial resistance
dc.subject AMR
dc.subject MIC
dc.subject MIC-shift
dc.subject ECOFF
dc.title Where have all the susceptible gonococci gone? A historical review of changes in MIC distribution over the past 75 years
dc.type
dc.type
dc.type
dc.date.updated 2019-12-29T04:10:10Z
dc.language.rfc3066 en
dc.rights.holder The Author(s).


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