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Browsing Journal Articles by Faculty "Faculty of Health Sciences"

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The 341C/T polymorphism in the GSTP1 gene is associated with increased risk of oesophageal cancer

Author: Li, Dongping ; Dandara, Collet ; Parker, M Iqbal Date: 2010 BACKGROUND: The Glutathione S-transferases (GSTs) comprise a group of enzymes that are critical in the detoxification of carcinogens. In this study the effects of polymorphisms in these genes on the risk of developing oesophageal squamous ... Read more c b
50 years of Emmonsia disease in humans: the dramatic emergence of a cluster of novel fungal pathogens

Author: Schwartz, Ilan S ; Kenyon, Chris ; Feng, Peiying ; Govender, Nelesh P ; Dukik, Karolina ; Sigler, Lynne ; Jiang, Yanping ; Stielow, J Benjamin ; Muñoz, José F ; Cuomo, Christina A ; Botha, Alfred ; Stchigel, Alberto M ; De Hoog, G Sybren Date: 2015 New species of Emmonsia-like fungi, with phylogenetic and clinical similarities to Blastomyces and Histoplasma, have emerged as causes of systemic human mycoses worldwide. They differ from classical Emmonsia species by producing a ... Read more c b
9β Polymorphism of the Glucocorticoid Receptor Gene Appears to Have Limited Impact in Patients with Addison’s Disease

Author: Ross, Ian Louis ; Dandara, Collet ; Swart, Marelize ; Lacerda, Miguel ; Schatz, Desmond ; Blom, Dirk Jacobus Date: 2014 BACKGROUND: Addison’s disease (AD) has been associated with an increased risk of cardiovascular disease. Glucocorticoid receptor polymorphisms that alter glucocorticoid sensitivity may influence metabolic and cardiovascular risk factors in ... Read more c b
A 40-50kDa Glycoprotein Associated with Mucus is Identified as α-1-Acid Glycoprotein in Carcinoma of the Stomach

Author: Chirwa, Nthato ; Govender, Dhirendra ; Ndimba, Bongani ; Lotz, Zoe ; Tyler, Marilyn ; Panieri, Eugenio ; KAHN, DELAWIR ; Mall, Anwar S Date: 2012 Background and Aim: Secreted gastric mucins are large O-glycosylated proteins of crude mucus gels which are aberrantly expressed in malignancy. An albumin associated 55-65kDa glycoprotein was previously shown in mucus gels in gastric cancer. ... Read more
A 52-Week Placebo-Controlled Trial of Evolocumab in Hyperlipidemia

Author: Blom, Dirk J ; Hala, Tomas ; Bolognese, Michael ; Lillestol, Michael J ; Toth, Phillip D ; Burgess, Lesley ; Ceska, Richard ; Roth, Eli ; Koren, Michael J ; Ballantyne, Christie M ; Monsalvo, Maria Laura ; Tsirtsonis, Kate ; Kim, Jae B ; Scott, Rob ; Wasserman, Scott M ; Stein, Evan A Date: 2014 BACKGROUND Evolocumab, a monoclonal antibody that inhibits proprotein convertase subtilisin/ kexin type 9 (PCSK9), significantly reduced low-density lipoprotein (LDL) cholesterol levels in phase 2 studies. We conducted a phase 3 trial to ... Read more
A biregional survey and review of first-line treatment failure and second-line paediatric antiretroviral access and use in Asia and southern Africa

Author: Unknown author Date: 2011 BackgroundTo better understand the need for paediatric second-line antiretroviral therapy (ART), an ART management survey and a cross-sectional analysis of second-line ART use were conducted in the TREAT Asia Paediatric HIV Observational ... Read more
A case for integrating human rights in public health policy

Author: London, Leslie Date: 2006 In a global environment where human rights and well-being are coming under increasing threat, both from the spectre of terrorism and from the counter-reaction to it,1 and where international governance systems continue to pay lip service to ... Read more
A comparative analysis of pharmacists’ perspectives on codeine use and misuse – a three country survey

Author: Carney, Tara ; Wells, John ; Parry, Charles D H ; McGuinness, Padraig ; Harris, Richard ; Van Hout, Marie C Date: 27 Mar 2018 Background The misuse of codeine is of increasing concern in a number of countries, particularly as this relates to over -the-counter pain and cough relief medication, and is also supplied as a prescription medicine. The study ... Read more c b
A comparative evaluation of PDQ-Evidence

Author: Johansen, Marit ; Rada, Gabriel ; Rosenbaum, Sarah ; Paulsen, Elizabeth ; Motaze, Nkengafac V ; Opiyo, Newton ; Wiysonge, Charles S ; Ding, Yunpeng ; Mukinda, Fidele K ; Oxman, Andrew D Date: 15 Mar 2018 Background A strategy for minimising the time and obstacles to accessing systematic reviews of health system evidence is to collect them in a freely available database and make them easy to find through a simple ‘Google-style’ ... Read more c b
A comparative risk assessment for South Africa in 2000: Towards promoting health and preventing disease

Author: Norman, Rosana ; Bradshaw, Debbie ; Schneider, Michelle ; Joubert, Jane ; Groenewald, Pam ; Lewin, Simon ; Steyn, Krisela ; Vos, Theo ; Loubscher, Ria ; Nannan, Nadine ; Nojilana, Beatrice ; Pieterse, Desiréé ; the South African Comparative Risk Assessment Collaborating Group Date: 2007 A landmark project of the Medical Research Council, the first South African National Burden of Disease (SA NBD) study, identified the underlying causes of premature mortality and morbidity experienced in South Africa in the year 2000. (1) ... Read more c b n
A comparison of indices of glucose metabolism in five black populations: data from modeling the epidemiologic transition study (METS)

Author: Atiase, Yacoba ; Farni, Kathryn ; Plange-Rhule, Jacob ; Luke, Amy ; Bovet, Pascal ; Forrester, Terrence G ; Lambert, Vicki ; Levitt, Naomi S ; Kliethermes, Stephanie ; Cao, Guichan ; Durazo-Arvizu, Ramon A ; Cooper, Richard S ; Dugas, Lara R Date: 15 Sep 2015 Background: Globally, Africans and African Americans experience a disproportionate burden of type 2 diabetes, compared to other race and ethnic groups. The aim of the study was to examine the association of plasma glucose with indices of ... Read more c b
A comparison of physician emigration from Africa to the United States of America between 2005 and 2015

Author: Duvivier, Robbert J ; Burch, Vanessa C ; Boulet, John R Date: 2017 BACKGROUND: Migration of health professionals has been a cause for global concern, in particular migration from African countries with a high disease burden and already fragile health systems. An estimated one fifth of African-born physicians ... Read more
A comparison of self-report and antiretroviral detection to inform estimates of antiretroviral therapy coverage, viral load suppression and HIV incidence in Kwazulu-Natal, South Africa

Author: Huerga, Helena ; Shiferie, Fisseha ; Grebe, Eduard ; Giuliani, Ruggero ; Farhat, Jihane B ; Van-Cutsem, Gilles ; Cohen, Karen Date: 29 Sep 2017 Background: Accurately identifying individuals who are on antiretroviral therapy (ART) is important to determine ART coverage and proportion on ART who are virally suppressed. ART is also included in recent infection testing algorithms used ... Read more c b
A comparison of self-report and antiretroviral detection to inform estimates of antiretroviral therapy coverage, viral load suppression and HIV incidence in Kwazulu-Natal, South Africa

Author: Huerga, Helena ; Shiferie, Fisseha ; Grebe, Eduard ; Giuliani, Ruggero ; Farhat, Jihane Ben ; Van Cutsem, Gilles ; Cohen, Karen Date: 2017 Accurately identifying individuals who are on antiretroviral therapy (ART) is important to determine ART coverage and proportion on ART who are virally suppressed. ART is also included in recent infection testing algorithms used to estimate ... Read more
A comparison of the conditional inference survival forest model to random survival forests based on a simulation study as well as on two applications with time-to-event data

Author: Nasejje, Justine B ; Mwambi, Henry ; Sabur, Natasha F ; Lesosky, Maia Date: 2017 Abstract Background Random survival forest (RSF) models have been identified as alternative methods to the Cox proportional hazards model in analysing time-to-event data. These methods, however, have been criticised for the bias that results ... Read more
A cost effective RFLP method to genotype Solute carrier organic anion 1B1 (SLCO1B1) c.1929A>C (p.Leu643Phe, rs34671512); a variant with potential effect on rosuvastatin pharmacokinetics

Author: Soko, Nyarai D ; Masimirembwa, Collen ; Dandara, Collet Date: 14 Jun 2018 Objective: This study describes a restriction fragment polymorphism protocol for rapidly screening the polymorphism SLCO1B1 c.1929A>C in genomic DNA samples. The polymorphism SLCO1B1 c.1929A>C has been associated with increased activity ... Read more
A cost-effective strategy for primary prevention of acute rheumatic fever and rheumatic heart disease in children with pharyngitis

Author: Irlam, James H ; Mayosi, Bongani M ; Engel, Mark E ; Gaziano, Thomas A Date: 2013 Primary prevention of acute rheumatic fever (ARF) and rheumatic heart disease (RHD) in children depends on prompt and effective diagnosis and treatment of pharyngitis at the primary level of care. Cost-effectiveness modeling shows that the ... Read more
A critical evaluation of the effectiveness of interventions for improving the well-being of caregivers of children with cerebral palsy: a systematic review protocol

Author: Dambi, Jermaine M ; Jelsma, Jennifer ; Mlambo, Tecla ; Chiwaridzo, Matthew ; Tadyanemhandu, Cathrine ; Chikwanha, Mildred T ; Corten, Lieselotte Date: 13 Jul 2016 Background: Over the years, family-centered care has evolved as the “gold standard” model for the provision of healthcare services. With the advent of family-centered approach to care comes the inherent need to provide support services to ... Read more c b
A decade of tobacco control: The South African case of politics, health policy, health promotion and behaviour change

Author: Reddy, Priscilla ; James, Shamagonam ; Sewpaul, Ronel ; Yach, Derek ; Resnicow, Ken ; Sifunda, Sibusiso ; Mthembu, Zanele ; Mbewu, Anthony Date: 2013 BACKGROUND: The South African (SA) government has implemented comprehensive tobacco control measures in line with the requirements of the Framework Convention on Tobacco Control. The effect of these measures on smoking prevalence and ... Read more
A descriptive study of treatment provision for problem alcohol drinking in adult males in Khayelitsha, Cape Town, South Africa

Author: Saban, Amina ; Morojele, Neo ; London, Leslie Date: 04 Dec 2017 Background: Poor, Black African males are underrepresented as patients in facilities that treat problem drinking in Cape Town, South Africa. Reasons for this remain unclear, but factors such as the kinds of treatment provided, perceptions of ... Read more c b

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