Browsing Journal Articles by Author "Raal, Frederick J"

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Efficacy and Safety of Evolocumab in Reducing Lipids and Cardiovascular Events

Author: Sabatine, Marc S ; Giugliano, Robert P ; Wiviott, Stephen D ; Raal, Frederick J ; Blom, Dirk J ; Robinson, Jennifer ; Ballantyne, Christie M ; Somaratne, Ransi ; Legg, Jason ; Wasserman, Scott M ; Scott, Robert ; Koren, Michael J ; Stein, Evan A Date: 2015 BACKGROUND: Evolocumab, a monoclonal antibody that inhibits proprotein convertase subtilisin-kexin type 9 (PCSK9), significantly reduced low-density lipoprotein (LDL) cholesterol levels in short-term studies. We conducted two extension studies ... Read more
RNA-based therapy in the management of lipid disorders: a review

Author: Blom, Dirk J ; Marais, Adrian D ; Moodley, Rajen ; van der Merwe, Nico ; van Tonder, Alet ; Raal, Frederick J Date: 23 Apr 2022 This review focuses on antisense oligonucleotides and small interfering ribonucleic acid therapies approved or under development for the management of lipid disorders. Recent advances in RNA-based therapeutics allow tissue-specific targeting ... Read more c b

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