Browsing Journal Articles by Author "O'Neill, Hester G"

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Characterization of domain-selective inhibitor binding in angiotensin-converting enzyme using a novel derivative of lisinopril

Author: Watermeyer, Jean M ; Kröger, Wendy L ; O'Neill, Hester G ; Sewell, Trevor B ; Sturrock, Edward D Date: 2010 Human ACE (angiotensin-converting enzyme) (EC 3.4.15.1) is an important drug target because of its role in the regulation of blood pressure via the renin–angiotensin–aldosterone system. Somatic ACE comprises two homologous domains, the differing ... Read more
Probing the basis of domain-dependent inhibition using novel ketone inhibitors of angiotensin-converting enzyme

Author: Watermeyer, Jean M ; Kroger, Wendy L ; O'Neill, Hester G ; Sewell, B Trevor ; Sturrock, Edward D Date: 2008 Human angiotensin-converting enzyme (ACE) has two homologous domains, the N and C domains, with differing substrate preferences. X-ray crystal structures of the C and N domains complexed with various inhibitors have allowed identification of ... Read more

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