Browsing PhD / Doctoral by Department "Institute of Infectious Disease and Molecular Medicine"

Now showing items 1-14 of 14

Adaptive changes in HIV-1 subtype c proteins during early infection and their effect on disease progression

Author: Treurnicht, Florette Kathleen Date: 2010 Read more
The characterization of a novel C-type lectin-like receptor, CLEC9A

Author: Huysamen, Cristal Date: 2008 Includes abstract. Includes bibliographical references (leaves 147-161). Read more
Data integration for the analysis of uncharacterized proteins in Mycobacterium tuberculosis

Author: Mazandu, Gaston Kuzamunu Date: 2010 Mycobacterium tuberculosis is a bacterial pathogen that causes tuberculosis, a leading cause of human death worldwide from infectious diseases, especially in Africa. Despite enormous advances achieved in recent years in controlling the disease, ... Read more
Deletion of IL-4 receptor alpha on dendritic cells renders BALB/c mice hypersusceptible to Leishmania major infection

Author: Hurdayal, Ramona Date: 2013 In BALB/c mice, susceptibility to infection with the intracellular parasite Leishmania major is driven largely by the development of T helper 2 (Th2) responses and the production of interleukin (IL)-4 and IL-13, which share a common receptor ... Read more
The evolutionary impacts of secondary structures within genomes of eukaryote-infecting single-stranded DNA viruses

Author: Muhire, Brejnev Muhizi Date: 2015 Secondary structures forming through base-pairing in virus genomes have been proven to regulate several processes during viral replication cycles, including genome replication, transcription, post-transcriptional activities, protein synthesis, ... Read more
Immunological characterization of the HIV-tuberculosis associated immune reconstitution inflammatory syndrome

Author: Tadokera, Rabecca Date: 2011 While the integration of anti-TB and cART therapies is associated with substantial clinical improvement in the majority of patients, HIV-Tuberculosis associated Immune Reconstitution Inflammatory Syndrome (TB-IRIS) has been shown to occur in ... Read more
Integration and visualisation of data in bioinformatics

Author: Salazar, Gustavo A Date: 2015 The most recent advances in laboratory techniques aimed at observing and measuring biological processes are characterised by their ability to generate large amounts of data. The more data we gather, the greater the chance of finding clues to ... Read more
Investigations of mycobacteria-specific memoryy/effector T cell responses in HIV infected children receiving antiretroviral therapy

Author: Tena-Coki, Nontobeko Gwendoline Date: 2011 Human immunodeficiency virus (HIV) infected children are at greater risk of developing tuberculosis disease, and might benefit from vaccination with novel TB vaccines. However, little is known about the effect of HIV-infection on function and ... Read more
Isolation And Molecular Characterization Of Shiga Toxin Producing Escherichia coli In Cattle, Water And Diarrhoeal Children From The Pastoral Systems Of Southwestern Uganda

Author: Majalija, Samuel Date: 2009 This study describes the molecular characteristics of STEC isolated from the pastoralist community of Nyabushozi in Southwestern Uganda. Faecal samples or rectal swabs of children with diarrhoea obtained in phases 1 and 2 were investigated ... Read more
Mapping genes underlying ethnic differences in tuberculosis risk by linkage disequilibrium in the South African coloured population of the Western Cape

Author: Rugamika, Emile Chimusa Date: 2013 The South Africa Coloured population of the Western Cape is the result of unions between Europeans, Africans (Bantu and Khoisan), and various other populations (Malaysian or Indonesian descent). The world-wide burden of tuberculosis remains ... Read more
Preconception maternal exposure to Nippostrongylus brasiliensis transfers protection against Nb to her offspring

Author: Darby, Matthew G Date: 2016 In early life the immature immune system has a reduced ability to control infection. This susceptibility is offset by transfer of protective immune components from the mother. Helminth infections are widespread and can have a long lasting ... Read more
Preparation and evaluation of polymer microspheres for enhanced lateral flow immunoassay: the case study for malaria

Author: Hobbs, Henriëtte Renée Date: 2015 We proposed that the development of a new high capacity polymer microsphere technology, termed ReSyn, could be developed as viable detection reagents for lateral flow technology. This body of work outlines the development of this new high ... Read more
Remodelling of Mycobacterial Peptidoglycan During Cell Division and the Epigenetics of Macrophages during M. tuberculosis infection

Author: Kieswetter, Nathan Scott Date: 2021 There are so many people who I would like to thank. If it takes a village to raise a child, it certainly takes a city to train a scientist. Firstly, I would like to thank my supervisors, A/Prof Reto Guler, Prof Frank Brombacher and Dr Mumin ... Read more
Tuberculosis transcriptomics: host protection and immune evasion mechanisms

Author: Ozturk, Mumin Date: 2017 Mycobacterium tuberculosis (Mtb) is the leading cause of death from an infectious disease. The success of the pathogen lies in its ability to subvert hostile intracellular macrophage environment. We performed genome-wide transcriptional deep ... Read more