Antibacterial and antimycobacterial activities of South African Salvia species and isolated compounds from S. chamelaeagnea

 

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dc.contributor.author Seaman, T
dc.contributor.author Kamatou, G P P
dc.contributor.author Van Vuuren, S F
dc.contributor.author Van Heerden, F R
dc.contributor.author Viljoen, A M
dc.date.accessioned 2018-05-16T13:07:59Z
dc.date.available 2018-05-16T13:07:59Z
dc.date.issued 2007
dc.identifier http://dx.doi.org/10.1016/j.sajb.2007.05.001
dc.identifier.citation Kamatou, G. P. P., Van Vuuren, S. F., Van Heerden, F. R., Seaman, T., & Viljoen, A. M. (2007). Antibacterial and antimycobacterial activities of South African Salvia species and isolated compounds from S. chamelaeagnea. South African Journal of Botany, 73(4), 552-557.
dc.identifier.uri http://hdl.handle.net/11427/28086
dc.description.abstract Extracts of 16 South African Salvia species commonly used in traditional medicine to treat various microbial infections were investigated for in vitro antibacterial and antimycobacterial activities using the micro-dilution and respiratory BACTEC method, respectively. The micro-organisms tested include two Gram-positive (Staphylococcus aureus and Bacillus cereus); two Gram-negative (Escherichia coli and Klebsiella pneumoniae) bacterial strains and the common pathogen responsible for tuberculosis, Mycobacterium tuberculosis. Extracts of the majority of species exhibited moderate to good antibacterial activity with minimum inhibitory concentration (MIC) values ranging from 0.03 to 8.00 mg/ml. Promising activity was observed against M. tuberculosis (MIC ≤ 0.50 mg/ml) with S. radula, S. verbenaca and S. dolomitica displaying the most favourable activity (MIC: 0.10 mg/ml). The antibacterial bioassay-guided fractionation of S. chamelaeagnea resulted in the isolation of four compounds: carnosol, 7-O-methylepirosmanol, oleanolic acid and its isomer ursolic acid as the active principles against S. aureus. The in vitro antibacterial and antimycobacterial activities may support the use of Salvia species in traditional medicine to treat microbial infections.
dc.source South African Journal of Botany
dc.source.uri http://www.sciencedirect.com/science/article/pii/S0254629907003079
dc.subject.other 7-O-Methylepirosmanol
dc.subject.other Antibacterial activity
dc.subject.other Antimycobacterial activity
dc.subject.other Carnosol
dc.subject.other Oleanolic acid
dc.subject.other Salvia
dc.subject.other Ursolic acid
dc.title Antibacterial and antimycobacterial activities of South African Salvia species and isolated compounds from S. chamelaeagnea
dc.date.updated 2016-01-13T10:32:06Z
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Division of Clinical Pharmacology en_ZA
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