Overview of a paediatric renal transplant programme

 

Show simple item record

dc.contributor.author McCulloch, M
dc.contributor.author Gajjar, P
dc.contributor.author Spearman, W
dc.contributor.author Burger, H
dc.contributor.author Sinclair, P
dc.contributor.author Savage, L
dc.contributor.author Morrison, C
dc.contributor.author Davies, C
dc.contributor.author Ruysch van Dugteren, GPA
dc.contributor.author Maytham, D
dc.contributor.author Wiggelinkhuizen, J
dc.contributor.author Pascoe, M D
dc.contributor.author McCurdie, F J
dc.contributor.author Pontin, A
dc.contributor.author Muller, E
dc.contributor.author Numanoglu, A
dc.contributor.author Millar, A J W
dc.contributor.author Rode, H
dc.contributor.author Khan, D
dc.date.accessioned 2017-06-30T06:52:07Z
dc.date.available 2017-06-30T06:52:07Z
dc.date.issued 2006
dc.identifier http://dx.doi.org/10.7196/SAMJ.1294
dc.identifier.citation McCulloch, M., Gajjar, P., Spearman, C., Burger, H., Sinclair, P., Savage, L., Morrison, C., Davies, C., van Dugteren, G., Maytham, D., Wiggelinkhuizen, J., Pascoe, M., McCurdie, F., Pontin, A., Muller, E., Numanoglu, A., Miller, A., Rode, H., & Kahn, D. (2006). Overview of a peadiatric renal transplant programme. South African Medical Journal, 96(9), 955.
dc.identifier.uri http://hdl.handle.net/11427/24668
dc.description.abstract INTRODUCTION: Renal transplantation is the therapy of choice for children with end-stage renal failure. There are many challenges associated with a paediatric programme in a developing country where organs are limited. METHODS: A retrospective review was undertaken of 149 paediatric renal transplants performed between 1968 and 2006 with specific emphasis on transplants performed in the last 10 years. Survival of patients and grafts was analysed and specific problems related to drugs and infections were reviewed. RESULTS: On review of the total programme, 60% of the transplants have been performed in the last 10 years, with satisfactory overall patient and graft survival for the first 8 years post transplant. At this point, transfer to adult units with non-compliance becomes a significant problem. Rejection is less of a problem than previously but infection is now a bigger issue--specifically tuberculosis (TB), cytomegalovirus (CMV) and Epstein-Barr virus (EBV) infections with related complications. A wide variety of drugs are available for tailoring immunosuppression to minimise side-effects. CONCLUSION: It is possible to have a successful paediatric transplant programme in a developing country. However, to improve long-term outcomes certain issues need to be addressed, including reduction of nephrotoxic drugs and cardiovascular risk factors and providing successful adolescent to adult unit transition.
dc.source South African Medical Journal
dc.source.uri http://www.samj.org.za/index.php/samj
dc.title Overview of a paediatric renal transplant programme
dc.type Journal Article en_ZA
dc.date.updated 2016-01-12T07:45:31Z
uct.type.publication Research en_ZA
uct.type.resource Article en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Division of Child and Adolescent Psychiatry en_ZA
uct.type.filetype Text
uct.type.filetype Image


Files in this item

This item appears in the following Collection(s)

Show simple item record