Synthesis of triazole-linked 2-trichloromethylquinazolines and exploration of their efficacy against P. falciparum

Journal Article

2013

Permanent link to this Item
http://hdl.handle.net/11427/19702
Files
Hamann_Synthesis_triazole_linked_2013.pdf (358.52 KB)
Authors
Hamann, A R
de Kock, C
Smith, P J
van Otterlo, W A
Blackie, M A
Journal Title

South African Journal of Chemistry-Suid-Afrikaanse Tydskrif Vir Chemie

Link to Journal
http://www.journals.co.za/sajchem/
Journal ISSN
Volume Title
Publisher

South African Chemical Institute

Publisher

University of Cape Town

Department
Department of Medicine
Faculty
Faculty of Health Sciences
License

http://creativecommons.org/licenses/by/4.0/

Series
Abstract
Using 2-trichloromethylquinazoline as scaffold, seven novel triazole-linked compounds have been synthesized using CuAAC chemistry. The in vitrobiological activity of four of the compounds on the Plasmodium falciparumchloroquine-sensitive strain NF54 was then determined. The compounds which were tested showed moderate activity with 1.45 /iM as the lowest inhibitory concentration.
Description
Keywords
malaria
2-trichloromethylquinazoline
copper click chemistry
1,2,3-triazole

Reference:

Hamann, A. R., De Kock, C., Smith, P. J., Van Otterlo, W. A., & Blackie, M. A. (2013). Synthesis of Triazole-linked 2-Trichloromethylquinazolines and Exploration of Their Efficacy Against P falciparum. South African Journal of Chemistry, 66, 231-236.

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