Obesity phenotypes in urban and rural Cameroonians: a cross-sectional study

 

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dc.contributor.author Mbanya, Vivian en_ZA
dc.contributor.author Echouffo-Tcheugui, Justin en_ZA
dc.contributor.author Akhtar, Hussain en_ZA
dc.contributor.author Mbanya, Jean-Claude en_ZA
dc.contributor.author Kengne, Andre en_ZA
dc.date.accessioned 2015-12-07T08:52:14Z
dc.date.available 2015-12-07T08:52:14Z
dc.date.issued 2015 en_ZA
dc.identifier.citation Mbanya, V. N., Echouffo-Tcheugui, J. B., Akhtar, H., Mbanya, J. C., & Kengne, A. P. (2015). Obesity phenotypes in urban and rural Cameroonians: a cross-sectional study. Diabetology & metabolic syndrome, 7(1), 21. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/15655
dc.identifier.uri http://dx.doi.org/10.1186/s13098-015-0016-5
dc.description.abstract BACKGROUND: Despite the increasing prevalence of diabetes and other health consequences of obesity, little is known on the metabolic profile across categories of body mass index (BMI) among African populations. We therefore assessed the prevalence and distribution of body size phenotypes among urban and rural Cameroonians. METHODS: Adults (n=1628; 41% rural dwellers) aged 24-74 years in 1994 provided data on BMI and metabolic health, defined on the basis of elevated levels of blood pressure (BP); triglycerides, fasting plasma glucose (FPG), and insulin resistance as assessed with homeostasis model assessment (HOMA). Cross-classification of BMI categories and metabolic status (healthy/unhealthy) created six groups. Metabolic measures include elevated blood pressure; elevated triglycerides ([greater than or equal to]150 mg/dL or 1.69mmo/L), elevated fasting plasma glucose ([greater than or equal to]100 mg/dl or 5.6 mmol/L or documented use of antidiabetic medications), and elevated homeostasis model assessment of insulin resistance value (HOMA-IR>90th percentile). RESULTS: A total of 25.2% of participants were overweight yet metabolically healthy (<1 abnormality) and 10.1% were obese yet metabolically healthy, whereas 1.4% were normal weight but metabolically abnormal ([greater than or equal to]2 abnormalities). Proportion of rural dwellers with abnormal metabolic phenotype across normal-weight, overweight, obese categories were 2.9%, 0.8% and 0.3%, respectively; and 0 .3%, 2.2% and 2.6% among urban dwellers. Metabolically abnormal participants increased linearly across BMI categories (p<0.001). BMI categories and metabolic status interacted to affect age, gender, BMI, FPG, triglycerides, and BP status distributions (all p<0.04). Metabolic status and residence (rural vs. urban) interacted to influence the distribution across BMI categories of diastolic BP, BMI, waist circumference, fasting and 2-hour glucose, triglycerides, HOMA-IR, and prevalent diabetes (all p<0.005), with differential occurrence of BMI categories and metabolic status among urban and rural participants. CONCLUSIONS: Metabolic healthy obesity and obesity with a favorable cardiometabolic profile are not uncommon among Cameroonians, including among rural dwellers; but the latter group tended to have a better profile. en_ZA
dc.language.iso eng en_ZA
dc.publisher BioMed Central Ltd en_ZA
dc.rights This is an Open Access article distributed under the terms of the Creative Commons Attribution License en_ZA
dc.rights.uri http://creativecommons.org/licenses/by/4.0 en_ZA
dc.source Diabetology & Metabolic Syndrome en_ZA
dc.source.uri http://www.dmsjournal.com/ en_ZA
dc.subject.other diabetes en_ZA
dc.subject.other obesity en_ZA
dc.title Obesity phenotypes in urban and rural Cameroonians: a cross-sectional study en_ZA
dc.type Journal Article en_ZA
dc.rights.holder 2015 Mbanya et al.; licensee BioMed Central. en_ZA
uct.type.publication Research en_ZA
uct.type.resource Article en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Department of Medicine en_ZA
uct.type.filetype Text
uct.type.filetype Image


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This is an Open Access article distributed under the terms of the Creative Commons Attribution License Except where otherwise noted, this item's license is described as This is an Open Access article distributed under the terms of the Creative Commons Attribution License