The T-box transcription factor, TBX3, is sufficient to promote melanoma formation and invasion

 

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dc.contributor.author Peres, Jade en_ZA
dc.contributor.author Prince, Sharon en_ZA
dc.date.accessioned 2015-11-27T09:32:39Z
dc.date.available 2015-11-27T09:32:39Z
dc.date.issued 2013 en_ZA
dc.identifier.citation Peres, J., & Prince, S. (2013). The T-box transcription factor, TBX3, is sufficient to promote melanoma formation and invasion. Mol Cancer, 12(1), 117-4598. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/15392
dc.identifier.uri http://dx.doi.org/10.1186/1476-4598-12-117
dc.description.abstract The T-box transcription factor, TBX3, is overexpressed in several cancers and has been proposed as a chemotherapeutic target. Several lines of evidence suggest that TBX3 may be a key contributor to malignant melanoma, a highly aggressive and intractable disease. Using in vitro and in vivo assays we demonstrate here for the first time that overexpressing TBX3 in non-tumourigenic early stage melanoma cells is sufficient to promote tumour formation and invasion. Furthermore, we show that TBX3 may play an important role as a reciprocal switch between substrate dependent cell proliferation and tumour invasion. en_ZA
dc.language.iso eng en_ZA
dc.publisher BioMed Central Ltd en_ZA
dc.rights This is an Open Access article distributed under the terms of the Creative Commons Attribution License en_ZA
dc.rights.uri http://creativecommons.org/licenses/by/2.0 en_ZA
dc.source Molecular Cancer en_ZA
dc.source.uri http://molecular-cancer.biomedcentral.com/ en_ZA
dc.subject.other TBX3 en_ZA
dc.subject.other Melanoma en_ZA
dc.subject.other Migration en_ZA
dc.subject.other Invasion en_ZA
dc.title The T-box transcription factor, TBX3, is sufficient to promote melanoma formation and invasion en_ZA
dc.type Journal Article en_ZA
dc.rights.holder Peres and Prince; licensee BioMed Central Ltd. 2013 en_ZA
uct.type.publication Research en_ZA
uct.type.resource Article en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Department of Human Biology en_ZA
uct.type.filetype Text
uct.type.filetype Image


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This is an Open Access article distributed under the terms of the Creative Commons Attribution License Except where otherwise noted, this item's license is described as This is an Open Access article distributed under the terms of the Creative Commons Attribution License