Human T cell lymphotropic virus type 1- associated infective dermatitis in KwaZulu Natal, South Africa

 

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dc.contributor.author Hlela, Carol en_ZA
dc.contributor.author Graham, Natalie en_ZA
dc.contributor.author Bhigjee, Ahmed en_ZA
dc.contributor.author Taylor, Graham en_ZA
dc.contributor.author Khumalo, Nonhlanhla en_ZA
dc.contributor.author Mosam, Anisa en_ZA
dc.date.accessioned 2015-11-23T11:39:27Z
dc.date.available 2015-11-23T11:39:27Z
dc.date.issued 2013 en_ZA
dc.identifier.citation Hlela, C., Graham, N., Bhigjee, A. I., Taylor, G. P., Khumalo, N. P., & Mosam, A. (2013). Human T cell lymphotropic virus type 1-associated infective dermatitis in KwaZulu Natal, South Africa. BMC dermatology, 13(1), 11. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/15227
dc.identifier.uri http://dx.doi.org/10.1186/1471-5945-13-11
dc.description.abstract BACKGROUND: The Human T cell lymphotropic virus type 1 (HTLV-1)-associated infective dermatitis (IDH), is a chronic relapsing dermatitis which usually presents in children older than 2years. A total of 300 cases have been reported worldwide (Latin America, the Caribbean and only 5 from Senegal). Neither IDH, nor its complications have been reported from the rest of Africa. We aimed to examine the clinical and aetiological characteristics of IDH in a cohort of South African children. METHODS: Attendees at the dermatology clinic at King Edward VIII Hospital, Durban underwent clinical examination. After obtaining consent those suspected of IDH had specimens taken for blood counts, immunoglobulins, serum protein electrophoresis, viral studies (including genotyping), skin swabs and stool examinations. RESULTS: Nineteen of 60 suspected cases recruited over 3years met the diagnostic criteria for IDH. The male-to-female ratio was 1:2; mean age 8years (range 0.7 to 15). Dermatitis mostly affected the scalp (78.9%) and axilla (73.7%); fewer children had nasal crusting (47.4%). Mean Ig A, IgG and IgM were raised, at 3.52g/l, 22.6g/l and 1.38g/l, respectively. The median CD4 cell count was 1958 cells/mm3. Viral genotyping of all tested samples were positive for the Cosmopolitan, Subtype A (HTLV-1a). CONCLUSIONS: IDH is a distinct entity which also affects South Africans. Our patients were older at presentation and the majority did not present with nasal crusting as has been described in other countries. en_ZA
dc.language.iso eng en_ZA
dc.publisher BioMed Central Ltd en_ZA
dc.rights This is an Open Access article distributed under the terms of the Creative Commons Attribution License en_ZA
dc.rights.uri http://creativecommons.org/licenses/by/2.0 en_ZA
dc.source BMC Dermatology en_ZA
dc.source.uri http://www.biomedcentral.com/bmcdermatol/ en_ZA
dc.subject.other Human T cell lymphotropic virus type 1 (HTLV-1) en_ZA
dc.subject.other infective dermatitis (IDH) en_ZA
dc.title Human T cell lymphotropic virus type 1- associated infective dermatitis in KwaZulu Natal, South Africa en_ZA
dc.type Journal Article en_ZA
dc.rights.holder 2013 Hlela et al.; licensee BioMed Central Ltd. en_ZA
uct.type.publication Research en_ZA
uct.type.resource Article en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Division of Dermatology en_ZA
uct.type.filetype Text
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This is an Open Access article distributed under the terms of the Creative Commons Attribution License Except where otherwise noted, this item's license is described as This is an Open Access article distributed under the terms of the Creative Commons Attribution License