Inflammation in the male genital tract: implications for HIV acquisition and transmission
Journal Article
2012
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Journal Title
Retrovirology
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BioMed Central Ltd
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University of Cape Town
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Abstract
Elevated plasma levels of pro-inflammatory mediators such as TNFα, IL-1β, IL-6 and IL-8, MIP-1α, MIP-1β and RANTES have been demonstrated in HIV-infected individuals and HIV induces higher levels of pro-inflammatory cytokines in the female genital tract. We characterized levels of inflammation in semen, to gain an understanding of factors influencing transmission and acquisition in the male genital tract. Our hypothesis was that infected men would exhibit higher levels of inflammation in semen than uninfected men.
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Reference:
Olivier, A. J., Roberts, L., Coetzee, D., Williamson, A., Passmore, J. S., & Burgers, W. A. (2012). Inflammation in the male genital tract: implications for HIV acquisition and transmission. Retrovirology, 9(Suppl 2), O23.