A prime-boost immunization with rBCG expressing HIV-1 Gag, RT and gp120 and SAAVI MVA-C elicits immune responses in blood and MALT of rhesus macaques

Journal Article

2012

Permanent link to this Item
http://hdl.handle.net/11427/15047
 http://dx.doi.org/10.1186/1742-4690-9-S2-P40
Files
Chege_prime_boost_immunization_2012.pdf (128.31 KB)
Authors
Chege, GK
Chapman, R
Shephard, EG
Williamson, A
Journal Title

Retrovirology

Link to Journal
http://www.retrovirology.com/
Journal ISSN
Volume Title
Publisher

BioMed Central Ltd

Publisher

University of Cape Town

Department
Division of Virology
Faculty
Faculty of Health Sciences
License

http://creativecommons.org/licenses/by/2.0

Series
Abstract
CG pantothenate auxtroph (ΔpanCD) is safer to use as a live vaccine vector than wild-type BCG. We constructed 3 recombinant BCGΔpanCD candidate vaccines expressing HIV-1 subtype C Gag, RT and Env (gp120). The current study investigated immune responses in rhesus macaques following a prime with a mixture of these rBCG vaccines and a boost with SAAVI MVA-C (MVA).
Description
Keywords
HIV-1 Peptide
HIV-1 Subtype
rBCG Vaccine
vaccine-specific Immune Response

Reference:

Chege, G. K., Chapman, R., Shephard, E. G., & Williamson, A. (2012). A prime-boost immunization with rBCG expressing HIV-1 Gag, RT and gp120 and SAAVI MVA-C elicits immune responses in blood and MALT of rhesus macaques. Retrovirology, 9(Suppl 2), P40.

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