P19-53 LB. Priming with recombinant BCG expressing HIV-1 Gag or RT and boosting with recombinant MVA induces an effective immune response in mice

 

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dc.contributor.author Stutz, H en_ZA
dc.contributor.author Powles, R en_ZA
dc.contributor.author Shephard, EG en_ZA
dc.contributor.author Williamson, A en_ZA
dc.date.accessioned 2015-11-04T11:45:19Z
dc.date.available 2015-11-04T11:45:19Z
dc.date.issued 2009 en_ZA
dc.identifier.citation Stutz, H., Powles, R., Shephard, E. G., & Williamson, A. (2009). P19-53 LB. Priming with recombinant BCG expressing HIV-1 Gag or RT and boosting with recombinant MVA induces an effective immune response in mice. Retrovirology, 6(Suppl 3), P417. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/14656
dc.identifier.uri http://dx.doi.org/10.1186/1742-4690-6-S3-P417
dc.description.abstract Mycobacterium bovis BCG (BCG) has a number of characteristics that give it great potential to act as a vehicle for the delivery of recombinant vaccines. However, its success depends on overcoming the challenges of poor antigen expression levels and genetic instability. Our studies using an optimized mycobacterial shuttle vector which utilizes the Mycobacterium tuberculosis mtrA promoter, induced upon infection of macrophages, and the M. tuberculosis 19 kDa signal sequence may overcome these issues. We have used this system to generate a recombinant BCG (rBCG) expressing HIV-1 subtype C full length Gag or reverse transcriptase (RT). en_ZA
dc.language.iso eng en_ZA
dc.publisher BioMed Central Ltd en_ZA
dc.rights This is an Open Access article distributed under the terms of the Creative Commons Attribution License en_ZA
dc.rights.uri http://creativecommons.org/licenses/by/2.0 en_ZA
dc.source Retrovirology en_ZA
dc.source.uri http://www.retrovirology.com/ en_ZA
dc.subject.other Wild Type BCG en_ZA
dc.subject.other Booster Vaccine en_ZA
dc.subject.other Antigen Specific CD8 en_ZA
dc.subject.other Primary Vaccine en_ZA
dc.subject.other rBCG Vaccine en_ZA
dc.subject.other ELISPOT Assay en_ZA
dc.title P19-53 LB. Priming with recombinant BCG expressing HIV-1 Gag or RT and boosting with recombinant MVA induces an effective immune response in mice en_ZA
dc.type Journal Article en_ZA
dc.rights.holder 2009 Stutz et al; licensee BioMed Central Ltd. en_ZA
uct.type.publication Research en_ZA
uct.type.resource Article en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Division of Medical Microbiology en_ZA
uct.type.filetype Text
uct.type.filetype Image


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This is an Open Access article distributed under the terms of the Creative Commons Attribution License Except where otherwise noted, this item's license is described as This is an Open Access article distributed under the terms of the Creative Commons Attribution License