• Restoration of cellular immunity in HIV-infected individuals on antiretroviral therapy

  

   Authors: Fatime Ramla, Tanko Date: 2017 During the course of HIV pathogenesis, the virus induces multiple defects in immune cells, altering their functional ability to efficiently control HIV itself and other infections. Whilst the widespread implementation of antiretroviral therapy ... Read more

• High Degree of HIV-1 group M Genetic Diversity within Circulating Recombinant Forms: Insight into the Early Events of HIV-1M Evolution

  

   Authors: Tongo, Marcel ; Dorfman, Jeffrey Robert ; Martin, Darren Patrick Date: 15 Mar 2016 The existence of various highly divergent HIV-1 lineages and of recombination-derived sequence tracts of indeterminate origin within established circulating recombinant forms (CRFs) strongly suggests that HIV-1 group M (HIV-1M) diversity is ... Read more

• Chinks in the armor of the HIV-1 Envelope glycan shield: implications for immune escape from anti-glycan broadly neutralizing antibodies

  

   Authors: Moyo, Thandeka ; Ferreira, Roux-cil ; Davids, Reyaaz ; Sonday, Zarinah ; Moore, Penny L ; Travers, Simon A ; Wood, Natasha T ; Dorfman, Jeffrey Robert Date: 15 Jan 2017 Glycans on HIV-1 Envelope serve multiple functions including blocking epitopes from antibodies. We show that removal of glycan 301, a major target of anti-V3/glycan antibodies, has substantially different effects in two viruses. While glycan ... Read more

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