The role of interleukin-4 receptor alpha on smooth muscle cells during helminth infection

Doctoral Thesis

2011

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University of Cape Town

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Abstract
Interleukin-4 receptor alpha (IL-4Ra) signaling, mediated by the ligands IL-4 and IL- 13, is important for effective host protection during murine Nippostrongylus brasiliensis (N. brasiliensis) and Schistosoma mansoni (S. manson!) infection. Among other cell types, IL-4Ra responsive smooth muscle cells influence immunological responses and are needed for host protection during N. brasiliensis and S. mansoni infection.
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Includes abstract.


Includes bibliographical references (leaves 101-111).

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