Synthesis and investigation of quinoline based ß-haematin formation inhibitors as potential antimalarials

Doctoral Thesis

2010

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University of Cape Town

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The question of whether or not replacing the 7-chloro group in the 4-aminoquinoline moiety with an electron withdrawing and hydrophilic substituent results in retention of antiplasmodial activity in the 4-aminoquinoline class of compounds was investigated...
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