L-arginine overproduction in Corynebacterium glutamicum ATCC 13032

 

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dc.contributor.advisor Reid, Sharon J en_ZA
dc.contributor.author Theron, Grant de V en_ZA
dc.date.accessioned 2015-01-13T03:59:24Z
dc.date.available 2015-01-13T03:59:24Z
dc.date.issued 2009 en_ZA
dc.identifier.citation Theron, G. 2009. L-arginine overproduction in Corynebacterium glutamicum ATCC 13032. University of Cape Town. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/12122
dc.description Includes abstract. en_ZA
dc.description Includes bibliographical references (p. 155-174). en_ZA
dc.description.abstract Corynebacterium glutamicum is widely used for the commercial production of a variety of amino acids, including L-lysine, L-glutamate and L-threonine. With the exception of Larginine, the biosynthesis and regulation of most of these compounds in this bacterium are relatively well characterised in the literature. The research presented here focuses on improving our understanding of the regulation of L-arginine biosynthesis in C. glutamicum. This was performed with the ultimate goal of creating strains capable of producing L-arginine commercially. A novel gene replacement system was initially used for the directed mutation of the Larginine biosynthetic gene cluster in C. glutamicum ATCC 13032. This was met with limited success, however, and the pK19mobsacB vector was thus adopted for further mutagenesis of this region. en_ZA
dc.language.iso eng en_ZA
dc.subject.other Cell Biology en_ZA
dc.title L-arginine overproduction in Corynebacterium glutamicum ATCC 13032 en_ZA
dc.type Thesis / Dissertation en_ZA
uct.type.publication Research en_ZA
uct.type.resource Thesis en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Science en_ZA
dc.publisher.department Department of Molecular and Cell Biology en_ZA
dc.type.qualificationlevel Doctoral en_ZA
dc.type.qualificationname PhD en_ZA
uct.type.filetype Text
uct.type.filetype Image


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