The aetiopathogenesis, cardiovascular and metabolic complications, and pharmacogenomics of Addison's disease in South Africa
Doctoral Thesis
2011
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University of Cape Town
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Abstract
This thesis aimed to address a number of
unanswered research questions in Addison's Disease: investigate whether autoimmunity is the
predominant cause of Addison's disease in South Africa and if a human leukocyte (HLA) DQ
antigen association exists; the extent to which lipids, lipoproteins and biochemical markers
of cardiovascular disease are abnormal; the degree to which replacement doses of hydrocortisone
are supra-physiological; the impact of glucocorticoid receptor (GCR) polymorphisms on risk factors,
markers of cardiovascular disease and replacement doses of hydrocortisone.
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Includes abstract.
Includes bibliographical references.
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Reference:
Ross, I. 2011. The aetiopathogenesis, cardiovascular and metabolic complications, and pharmacogenomics of Addison's disease in South Africa. University of Cape Town.