Studies on in vitro human T cell reactivity to antigens of mycobacterium tuberculosis

Doctoral Thesis

2010

Permanent link to this Item
http://hdl.handle.net/11427/10500
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thesis_hsf_2010_gideon_h_p.pdf (5.41 MB)
Authors
Gideon, Hannah Priyadarshini
Supervisors
Wilkinson, Robert J
Wilkinson, Katalin
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Volume Title
Publisher
Publisher

University of Cape Town

Department
Division of Medical Microbiology
Faculty
Faculty of Health Sciences
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Abstract
Studies on Mycobacterium tuberculosis (MTB) antigens are important to improve immunodiagnostics and vaccine efficacy. A novel genome based strategy for antigen discovery is to relate what is highly expressed by bacilli in vivo or in vitro, to what is recognized by human T cells as antigens. As hypoxia is a relevant stimulus that MTB encounters in vivo, whole genome based transcriptional profiles of M. tuberculosis subject to prolonged hypoxia (described as the Enduring hypoxic response (EHR) were analyzed, to guide the discovery of novel potential anitgens, by a combined bioinformatic and empirical approach and to determine evidence of infection stage specific recognition.
Description
Keywords
Medical Microbiology

Reference:

Gideon, H. 2010. Studies on in vitro human T cell reactivity to antigens of mycobacterium tuberculosis. University of Cape Town.

Collections
PhD / Doctoral