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Browsing by Author "Wood, Robin"

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Acute dichromate poisoning following the use of toxic purgatives

Author: Wood, Robin Date: 1990 During the last ten years, several patients have presented to the Renal Unit of Groote Schuur Hospital with acute renal failure following the use of traditional (N'anga or Gqirha) medication. The history together with abnormal liver-function ... Read more
Acute dichromate poisoning following the use of toxic purgatives

Author: Wood, Robin Date: 1990 During the last ten years, several patients have presented to the Renal Unit of Groote Schuur Hospital with acute renal failure following the use of traditional (N'anga or Gqirha) medication. The history together with abnormal liver-function ... Read more
Adjusting mortality for loss to follow-up: analysis of five ART programmes in sub-Saharan Africa

Author: Brinkhof, Martin W G ; Spycher, Ben D ; Yiannoutsos, Constantin ; Weigel, Ralf ; Wood, Robin ; Messou, Eugène ; Boulle, Andrew ; Egger, Matthias ; Sterne, Jonathan A C ; (IeDEA), for the International epidemiological Database to Evaluate AIDS Date: 2010 BACKGROUND: Evaluation of antiretroviral treatment (ART) programmes in sub-Saharan Africa is difficult because many patients are lost to follow-up. Outcomes in these patients are generally unknown but studies tracing patients have shown ... Read more c b
Antiretroviral therapy in a community clinic - early lessons from a pilot project

Author: Bekker, Linda-Gail ; Orrell, Catherine ; Reader, Larissa ; Matoti, Larissa ; Cohen, Karen ; Martell, Rob ; Abdullah, Fareed ; Wood, Robin Date: 2003 Objectives. To report on operational and clinical problems encountered during the first 6 months of a community-based antiretroviral therapy (ART) programme. Methods. ART was implemented in a primary care setting utilising an easily replicable ... Read more c b n
Antiretroviral treatment cohort analysis using time-updated CD4 counts: assessment of bias with different analytic methods

Author: Kranzer, Katharina ; Lewis, James J ; White, Richard G ; Glynn, Judith R ; Lawn, Stephen D ; Middelkoop, Keren ; Bekker, Linda-Gail ; Wood, Robin Date: 2011 BACKGROUND: Survival analysis using time-updated CD4+ counts during antiretroviral therapy is frequently employed to determine risk of clinical events. The time-point when the CD4+ count is assumed to change potentially biases effect estimates ... Read more c b
Are the effects of isoniaid preventive therapy and highly active antiretroviral therapy additive in preventing HIV-associated tuberculosis

Author: Wood, Robin ; Lawn, Stephen D ; Bekker, Linda-Gail Date: 2009 Golub et al. [1] recently reported a retrospective analysis of rates of incident tuberculosis (TB) in a large observational cohort of 2778 patients accessing HIV care in rural and urban South Africa. The TB incidence rate was highest [7.1/100 ... Read more
Are the effects of isoniaid preventive therapy and highly active antiretroviral therapy additive in preventing HIV-associated tuberculosis

Author: Wood, Robin ; Lawn, Stephen D ; Bekker, Linda-Gail Date: 2009 Golub et al. [1] recently reported a retrospective analysis of rates of incident tuberculosis (TB) in a large observational cohort of 2778 patients accessing HIV care in rural and urban South Africa. The TB incidence rate was highest [7.1/100 ... Read more
Asking the right questions: developing evidence-based strategies for treating HIV in women and children

Author: Karim, Quarraisha ; Banegura, Anchilla ; Cahn, Pedro ; Christie, Celia ; Dintruff, Robert ; Distel, Manuel ; Hankins, Catherine ; Hellmann, Nicholas ; Katabira, Elly ; Lehrman, Sandra ; Montaner, Julio ; Purdon, Scott ; Rooney, James ; Wood, Robin ; Heidari, Shiri Date: 2011 In July 2010, the World Health Organization (WHO) issued formal revisions of its guidelines on the use of highly active antiretroviral therapy for HIV. The new guidelines greatly expand eligibility for treatment of adults and children, as ... Read more c b
Blood neutrophil counts in HIV-infected patients with pulmonary tuberculosis: association with sputum mycobacterial load

Author: Kerkhoff, Andrew D ; Wood, Robin ; Lowe, David M ; Vogt, Monica ; Lawn, Stephen D Date: 2013 BACKGROUND: Increasing evidence suggests that neutrophils play a role in the host response to Mycobacterium tuberculosis . We determined whether neutrophil counts in peripheral blood are associated with tuberculosis (TB) and with mycobacterial ... Read more c b
Burden of new and recurrent tuberculosis in a major South African city stratified by age and HIV-status

Author: Wood, Robin ; Lawn, Stephen D ; Caldwell, Judy ; Kaplan, Richard ; Middelkoop, Keren ; Bekker, Linda-Gail Date: 2011 Aim: To describe the burden of tuberculosis (TB) in Cape Town by calculating TB incidence rates stratified by age and HIV-status, assessing the contribution of retreatment disease and estimating the cumulative lifetime TB risk in HIV-negative ... Read more c b
CD4 cell count recovery among HIV-infected patients with very advanced immunodeficiency commencing antiretroviral treatment in sub-Saharan Africa

Author: Lawn, Stephen ; Myer, Landon ; Bekker, Linda-Gail ; Wood, Robin Date: 2006 BACKGROUND:Patients accessing antiretroviral treatment (ART) programmes in sub-Saharan Africa frequently have very advanced immunodeficiency. Previous data suggest that such patients may have diminished capacity for CD4 cell count recovery. ... Read more c b
A century of tuberculosis epidemiology in the northern and southern hemisphere: the differential impact of control interventions

Author: Hermans, Sabine ; Jr, C Robert Horsburgh ; Wood, Robin Date: 2015 BACKGROUND: Cape Town has one of the highest TB burdens of any city in the world. In 1900 the City of Cape Town, New York City and London had high mortality of tuberculosis (TB). Throughout the 20th century contemporaneous public health ... Read more c b
Childhood tuberculosis infection and disease: A spatial and temporal transmission analysis in a South African township

Author: Middelkoop, Keren ; Bekker, Linda-Gail ; Morrow, Carl ; Zwane, Eugene ; Wood, Robin Date: 2009 Background. Tuberculosis (TB) remains a leading cause of South African mortality and morbidity. While adult TB arises from both recent and prior infection, childhood TB results from recent infection and reflects ongoing transmission occurring ... Read more
The clinical and economic impact of point-of-care CD4 testing in Mozambique and other resource-limited settings: a cost-effectiveness analysis

Author: Hyle, Emily P ; Jani, Ilesh V ; Lehe, Jonathan ; Su, Amanda E ; Wood, Robin ; Quevedo, Jorge ; Losina, Elena ; Bassett, Ingrid V ; Pei, Pamela P ; Paltiel, A David Date: 2014 Emily Hyle and colleagues conduct a cost-effectiveness analysis to estimate the clinical and economic impact of point-of-care CD4 testing compared to laboratory-based tests in Mozambique. Please see later in the article for the Editors' Summary Read more c b
A comparison of death recording by health centres and civil registration in South Africans receiving antiretroviral treatment

Author: Johnson, Leigh F ; Dorrington, Rob E ; Laubscher, Ria ; Hoffmann, Christopher J ; Wood, Robin ; Fox, Matthew P ; Cornell, Morna ; Schomaker, Michael ; Prozesky, Hans ; Tanser, Frank ; Davies, Mary-Ann ; Boulle, Andrew Date: 16 Dec 2015 Introduction: There is uncertainty regarding the completeness of death recording by civil registration and by health centres in South Africa. This paper aims to compare death recording by the two systems, in cohorts of South African patients ... Read more c b
Comparison of six methods to estimate adherence in an ART-naïve cohort in a resource-poor setting: which best predicts virological and resistance outcomes?

Author: Orrell, Catherine ; Cohen, Karen ; Leisegang, Rory ; Bangsberg, David R ; Wood, Robin ; Maartens, Gary Date: 04 Apr 2017 Background: Incomplete adherence to antiretroviral therapy (ART) results in virologic failure and resistance. It remains unclear which adherence measure best predicts these outcomes. We compared six patient-reported and objective adherence ... Read more
Corneal endothelial cells provide evidence of accelerated cellular senescence associated with HIV infection: a case-control study

Author: Pathai, Sophia ; Lawn, Stephen D ; Shiels, Paul G ; Weiss, Helen A ; Cook, Colin ; Wood, Robin ; Gilbert, Clare E Date: 2013 BACKGROUND: Cellular senescence may be a key factor in HIV-related premature biological aging. We assessed features of the corneal endothelium that are known to be associated with biological aging, and cellular senescence markers in HIV-infected ... Read more c b
Correcting mortality for loss to follow-up: a nomogram applied to antiretroviral treatment programmes in sub-Saharan Africa

Author: Egger, Matthias ; Spycher, Ben D ; Sidle, John ; Weigel, Ralf ; Geng, Elvin H ; Fox, Matthew P ; MacPhail, Patrick ; van Cutsem, Gilles ; Messou, Eugène ; Wood, Robin Date: 2011 Background: The World Health Organization estimates that in sub-Saharan Africa about 4 million HIV-infected patients had started antiretroviral therapy (ART) by the end of 2008. Loss of patients to follow-up and care is an important problem ... Read more c b
Correction to: Bioaerosol sampling of patients with suspected pulmonary tuberculosis: a study protocol

Author: Patterson, Benjamin ; Koch, Anastasia ; Gessner, Sophia ; Dinkele, Ryan ; Gqada, Melitta ; Bryden, Wayne ; Cobelens, Frank ; Little, Francesca ; Warner, Digby F ; Wood, Robin Date: 24 Aug 2020 An amendment to this paper has been published and can be accessed via the original article Read more
Cost effectiveness of cryptococcal antigen screening as a strategy to prevent HIV-associated cryptococcal meningitis in South Africa

Author: Jarvis, Joseph N ; Harrison, Thomas S ; Lawn, Stephen D ; Meintjes, Graeme ; Wood, Robin ; Cleary, Susan Date: 2013 Objectives Cryptococcal meningitis (CM)-related mortality may be prevented by screening patients for sub-clinical cryptococcal antigenaemia (CRAG) at antiretroviral-therapy (ART) initiation and pre-emptively treating those testing positive. ... Read more c b

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