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Browsing by Author "Opie, Lionel H"

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Adenosine and its role in cardioplegia : experimental evaluation in the isolated rat heart and in an-vivo primate model

Author: Boehm, Dieter Hermann Date: 1997 This study was designed to investigate the role of adenosine, an endogenous cardioprotectant agent, without high potassium and as cardioplegic additive to high potassium solutions. Adenosine cardioplegia and potassium cardioplegia supplemented ... Read more
Cardioprotective role of signal transducer activator of transcription 3 (STAT-3) against ischaemai reperfusion injuries

Author: King, Jonathan Chan Date: 2011 Introduction: Sphingosine 1 phosphate (S1P) is a major constituent of high density lipoprotein (HDL) cholesterol. Both S1P preconditioning and ischaemic postconditioning reduce myocardial damage following an ischaemia-reperfusion insult but ... Read more
Delineation of the Cardioprotective Agents found in red wine

Author: Lamont, Kim Date: 2009 Secondary leach concentrate (SLC) is an important bleed stream for minor elements from Anglo Platinum's Base Metal Refinery (BMR) which produces copper nickel and cobalt sulphate. It contains mainly sulphur, iron jarosites, unleached base ... Read more
Electrophysiological mechanism of ventricular automaticity : a model foe ventricular arrythmias

Author: Saman, Selva ; Saman, Selva Date: 1984 Ventricular arrhythmias are difficult to study in man. The current experimental models are arrhythmias induced by electrical stimulation, coronary artery ligation or by subsequent reperfusion. An electrophysiological model will be useful for ... Read more
The energy substrate switch during cardiac development, with the onset of cardiac hypertrophy and the transition to heart failure. : delineation and characterisation of gene regulatory mechanisms : "changing concepts of metabolic regulation in the h

Author: Sack, Michael N Date: 2000 Bibliography: leaves 168-190. Read more
Exercise and the heart : effects of exercise training on coronary artery disease and on myocardial function, metabolism and vulnerability to ventricular fibrillation

Author: Noakes, Timothy D Date: 1981 There is epidemiological and experimental evidence suggesting that exercise training may reduce the mortality rate from coronary heart disease, in particular the sudden death rate, and that it may improve the peak functional capacity of the ... Read more
Infarct size and free fatty acids in the early phase of acute myocardial infarction

Author: Tansey, M J B Date: 1980 The management of acute myocardial infarction (AMI) has been improved by the realisation that the size of infarction can influence mortality (Sobel et al, 1972) and that the infarct size can be altered by subsequent therapy (Maroko et al, ... Read more
Metabolism in myocardial ischaemia and reperfusion with specific reference to the role of glucose

Author: King, Linda Mary Date: 1996 Hypothesis: Glucose is known to be protective in moderate low flow ischaemia due to the production of glycolytic ATP. However, it is questioned whether glucose would still be protective in ultra-low flow ischaemia. Firstly, glycolysis is ... Read more
Myocardial intermediary metabolism: with special reference to the isolated, contracting, perfused rat heart

Author: Opie, Lionel H Date: 1961 Studies of myocardial metabolism In vivo have been considerably advanced by the introduction of coronary sinus catheterization. By determining the coronary arterio-venous differences of various substrates, Sing and other workers (Goodale, ... Read more
The pharmacological modification of reperfusion injury with particular reference to calcium fluxes in the isolated rat heart

Author: Du Toit, Eugene Francois Date: 1994 Myocardial reperfusion injury is thought to be caused by reperfusion induced i) cytosolic Ca²⁺ overload and/or, ii) the formation of oxygen derived freeradicals. At the start of this study, data implicating cytosolic Ca²⁺ overload in the ... Read more
PKCε and cardioprotection : an exploration of putative mechanisms

Author: McCarthy, Joy Date: 2006 Recent studies have investigated the underlying regulatory mechanisms that may explain the cardioprotective role of PKCε. Sub-proteome analysis has identified interactions between activated PKCε and various mitochondrial proteins, which ... Read more
Preconditioning and augmented preconditioning via manipulation of metabolic and signalling pathways in the rat heart

Author: Makaula, Siyanda S S Date: 2000 Cardiac ischaemic preconditioning (IPC) describes a biological phenomenon whereby a short ischaemic stimulus confers protection to the heart against subsequent prolonged ischaemia and reperfusion injury. Understanding this survival programme ... Read more
The role of melatonin in red wine-induced cardioprotection

Author: Lamont, Kim Date: 2012 Several epidemiological studies have suggested that the regular moderate consumption of red wine confers cardioprotection. However, the exact components in red wine that confer this effect are unclear. Previous studies performed in our ... Read more
Role of nuclear factors kappa-B in TNFα-induced cytoprotection

Author: Somers, Sarin J Date: 2006 Includes bibliographical references (leaves 67-81). Read more
The role of sublethal stress on mitochondria and the development of cardiac preconditioning

Author: Minners, Jan O Date: 2003 Cardiac preconditioning describes a cell survival program whereby a trigger renders the heart partially resistant to subsequent ischaemia/reperfusion induced cell death. Read more
The role of Toll-like receptor 4 (TLR-4) in wine-induced cardioprotection

Author: Albertyn, Zulfah Date: 2012 Moderate and chronic consumption of red wine confers cardioprotection. Melatonin, present in wine, may contribute to this cardioprotective effect. Melatonin confers cardioprotection via the activation of tumor necrosis factoralpha (TNF-α) ... Read more
Signalling pathways involved in TNFα-induced cytoprotection : role of reactive oxygen species

Author: Lacerda, Lydia Date: 2005 Tumour necrosis factor alpha (TNFa) is a pleiotropic cytokine which has both beneficial and deleterious effects. It has previously been shown in our laboratory that TNFa can mimic ischemic preconditioning (IPC). However, the signalling pathways ... Read more
Testing metabolic and pharmacological agents for recovery following de novo acute heart failure in an isolated rat heart model

Author: Deshpande, Gaurang Date: 2014 Acute heart failure is a potentially lethal clinical emergency without any effective therapy. Using an isolated rat heart model, we established and validated a model of de novo acute heart failure to study novel putative cardio protective ... Read more
Time is muscle : a systematic review investigating the role of remote ischaemic preconditioning and glucose-insulin-potassium infusions as adjunctive therapies to revascularisation in coronary artery disease

Author: Mothilal, Shikar Date: 2015 In the management of coronary artery disease (CAD) most advances have concerned improvements in catheter-based interventional techniques and complex pharmacotherapy, with an emphasis on time, which unfortunately, cannot always achieved. ... Read more