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Browsing by Author "Meintjes, Graeme"

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Adult meningitis in a setting of high HIV and TB prevalence: findings from 4961 suspected cases

Author: Jarvis, Joseph ; Meintjes, Graeme ; Williams, Anthony ; Brown, Yolande ; Crede, Tom ; Harrison, Thomas Date: 2010 BACKGROUND: The presentation and causes of adult meningitis in South Africa have changed substantially as a result of HIV. Knowledge of aetiology and laboratory findings in patients presenting with meningitis are important in guiding management. ... Read more c b
Altered ratio of IFN-γ/IL-10 in patients with drug resistant Mycobacterium tuberculosis and HIV-tuberculosis immune reconstitution inflammatory syndrome

Author: Skolimowska, Keira H ; Rangaka, Molebogeng X ; Meintjes, Graeme ; Pepper, Dominique J ; Seldon, Ronnett ; Matthews, Kerryn ; Wilkinson, Robert J ; Wilkinson, Katalin A Date: 2012 We have described a clinical relationship between HIV-Tuberculosis Immune Reconstitution Inflammatory Syndrome (TB-IRIS) and anti-tubercular drug resistance. Here we studied the immune response of TB-IRIS patients from whom a drug-resistant ... Read more c b
An evidence-based algorithm for the rapid diagnosis of tuberculosis in HIV positive patients presenting to emergency centres

Author: van Hoving, Daniël J Date: 2021 Background Tuberculosis remains a prevalent and deadly global disease. Diagnostic delays are partly due to reduced diagnostic performance of tuberculosis tests in HIV-positive people. The use of reliable pointof-care and near-patient diagnostic ... Read more
Antiretroviral treatment outcomes amongst older adults in a large multicentre cohort in South Africa

Author: Fatti, Geoffrey ; Mothibi, Eula ; Meintjes, Graeme ; Grimwood, Ashraf Date: 2014 Introduction Increasing numbers of patients are starting antiretroviral treatment (ART) at advanced age or reaching advanced age while on ART. We compared baseline characteristics and ART outcomes of older adults (aged ≥55 years) vs. younger ... Read more c b
Assessment at antiretroviral clinics during TB treatment reduces loss to follow-up among HIV-infected patients

Author: Pepper, Dominique J ; Marais, Suzaan ; Bhaijee, Feriyl ; Wilkinson, Robert J ; De Azevedo, Virginia ; Meintjes, Graeme Date: 2012 Setting: A South African township clinic where loss to follow-up during TB treatment may prevent HIV-infected TB patients from receiving life-saving ART. Objective: To determine factors associated with loss to follow-up during TB treatment. ... Read more c b
Assessment of lung function abnormalities in adult patients with tuberculosis in a high HIV-prevalent setting and the impact of a pulmonary rehabilitation intervention to improve lung function, functional capacity, and quality of life

Author: Manie, Shamila Date: 2022 Background: Globally, tuberculosis (TB) continues to be a major health problem. In the most recent World Health Organisation (WHO) Global Tuberculosis Report of 2019, TB was ranked as the leading cause of death from an infectious disease ahead ... Read more
Barriers to initiation of antiretrovirals during antituberculosis therapy in Africa

Author: Pepper, Dominique J ; Marais, Suzaan ; Wilkinson, Robert J ; Bhaijee, Feriyl ; De Azevedo, Virginia ; Meintjes, Graeme Date: 2011 BACKGROUND: In the developing world, the principal cause of death among HIV-infected patients is tuberculosis (TB). The initiation of antiretroviral therapy (ART) during TB therapy significantly improves survival, however it is not known which ... Read more c b
Cerebrospinal Fluid Cytokine Profiles Predict Risk of Early Mortality and Immune Reconstitution Inflammatory Syndrome in HIV-Associated Cryptococcal Meningitis

Author: Jarvis, Joseph N ; Meintjes, Graeme ; Bicanic, Tihana ; Buffa, Viviana ; Hogan, Louise ; Mo, Stephanie ; Tomlinson, Gillian ; Kropf, Pascale ; Noursadeghi, Mahdad ; Harrison, Thomas S Date: 2015 Author Summary Cryptococcal meningitis is a severe opportunistic infection, estimated to kill several hundred thousand HIV-infected individuals each year. One of the factors contributing to this high death toll is the inadequacy of antifungal ... Read more c b
Characterization of and risk factors for HIV-1 resistance mutations following first line antiretroviral failure in the southern African private sector

Author: Lutaaya, Leonard Edgar Date: 2017 Background: First-line antiretroviral therapy (ART) regimen choices have evolved over the past 15 years in South Africa. Many patients develop HIV drug resistance mutations when they fail first-line ART. The effect of different drug regimens ... Read more
Clinical and financial burdens of secondary level care in a public sector antiretroviral roll-out setting (G F Jooste Hospital)

Author: Kevany, Sebastian ; Meintjes, Graeme ; Rebe, Kevin ; Maartens, Gary ; Cleary, Susan Date: 2009 Background: Antiretroviral therapy (ART) is being extended across South Africa. While efforts have been made to assess the costs of providing ART via accredited service points, little information is available on its downstream costs, particularly ... Read more c b
Clinical deterioration during antitubercular treatment at a district hospital in South Africa: the importance of drug resistance and AIDS defining illnesses

Author: Pepper, Dominique J ; Rebe, Kevin ; Morroni, Chelsea ; Wilkinson, Robert J ; Meintjes, Graeme Date: 2009 BACKGROUND: Clinical deterioration on drug therapy for tuberculosis is a common cause of hospital admission in Africa. Potential causes for clinical deterioration in settings of high HIV-1 prevalence include drug resistant Mycobacterium ... Read more c b
Clinical deterioration during antituberculosis treatment in Africa: Incidence, causes and risk factors

Author: Pepper, Dominique ; Marais, Suzaan ; Wilkinson, Robert ; Bhaijee, Feriyl ; Maartens, Gary ; McIlleron, Helen ; De Azevedo, Virginia ; Cox, Helen ; McDermid, Cheryl ; Sokhela, Simiso ; Patel, Janisha ; Meintjes, Graeme Date: 2010 BACKGROUND:HIV-1 and Mycobacterium tuberculosis cause substantial morbidity and mortality. Despite the availability of antiretroviral and antituberculosis treatment in Africa, clinical deterioration during antituberculosis treatment remains ... Read more c b
Complications of antiretroviral therapy initiation in hospitalised patients with HIV-associated tuberculosis

Author: van der Plas, Helen ; Meintjes, Graeme ; Schutz, Charlotte ; Goliath, Rene ; Myer, Landon ; Baatjie, Dorothea ; Wilkinson, Robert J ; Maartens, Gary ; Mendelson, Marc Date: 2013 BACKGROUND: HIV-associated tuberculosis is a common coinfection in Sub-Saharan Africa, which causes high morbidity and mortality. A sub-set of HIV-associated tuberculosis patients require prolonged hospital admission, during which antiretroviral ... Read more c b
Correction to: AMBIsome Therapy Induction OptimisatioN (AMBITION): High Dose AmBisome for Cryptococcal Meningitis Induction Therapy in sub-Saharan Africa: Study Protocol for a Phase 3 Randomised Controlled Non-Inferiority Trial

Author: Lawrence, David S ; Youssouf, Nabila ; Molloy, Síle F ; Alanio, Alexandre ; Alufandika, Melanie ; Boulware, David R ; Boyer-Chammard, Timothée ; Chen, Tao ; Dromer, Francoise ; Hlupeni, Admire ; Hope, William ; Hosseinipour, Mina C ; Kanyama, Cecilia ; Lortholary, Oliver ; Loyse, Angela ; Meya, David B ; Mosepele, Mosepele ; Muzoora, Conrad ; Mwandumba, Henry C ; Ndhlovu, Chiratidzo E ; Niessen, Louis ; Schutz, Charlotte ; Stott, Katharine E ; Wang, Duolao ; Lalloo, David G ; Meintjes, Graeme ; Jaffar, Shabbar ; Harrison, Thomas S ; Jarvis, Joseph N Date: 14 Jan 2019 Following publication of the original article [1], we have been notified that one of the author names was listed incorrectly. Both incorrect and correct author names are presented below. The original publication has been corrected. Read more
Cost effectiveness of cryptococcal antigen screening as a strategy to prevent HIV-associated cryptococcal meningitis in South Africa

Author: Jarvis, Joseph N ; Harrison, Thomas S ; Lawn, Stephen D ; Meintjes, Graeme ; Wood, Robin ; Cleary, Susan Date: 2013 Objectives Cryptococcal meningitis (CM)-related mortality may be prevented by screening patients for sub-clinical cryptococcal antigenaemia (CRAG) at antiretroviral-therapy (ART) initiation and pre-emptively treating those testing positive. ... Read more c b
Cryptococcal immune reconstitution inflammatory syndrome presenting with erosive bone lesions, arthritis and subcutaneous abscesses

Author: Burton, Rosie ; Gogela, Neliswa ; Rebe, Kevin ; McNally, Matt ; Meintjes, Graeme Date: 2009 A 35-year-old South African man was diagnosed with pulmonary tuberculosis (TB) in August 2007 and started on a 6-month course of treatment (intensive phase of rifampicin, isoniazid, ethambutol and pyrazinamide for 2 months, followed by ... Read more
Diagnosis, treatment and determinants of mortality in patients hospitalized with HIV-associated tuberculosis

Author: Schutz,Charlotte Date: 2021 Background: HIV-associated tuberculosis (HIV-TB) comprises 9% of global tuberculosis cases but contributes a disproportionate 17% of tuberculosis deaths. Tuberculosis is the leading cause of death, hospitalization and in-hospital death in ... Read more
Diagnosis, treatment and immunopathogenesis of the HIV-associated tuberculosis immune reconstitution inflammatory syndrome

Author: Meintjes, Graeme Date: 2011 The paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) is a frequent complication of antiretroviral therapy (ART) among patients who start ART while on treatment for tuberculosis (TB). The condition ... Read more
Differential proteomic profiling towards elucidation of TB-IRIS pathogenesis

Author: Peyper, Janique Michelle Date: 2022 Background Up to 59% of tuberculosis (TB)/human immunodeficiency virus (HIV) co-treated patients develop paradoxical TB-associated immune reconstitution inflammatory syndrome (TB-IRIS) after addition of antiretroviral (ARV) therapy to ... Read more
Early severe morbidity and resource utilization in South African adults on antiretroviral therapy

Author: de Cherif, Teresa ; Schoeman, Jan ; Cleary, Susan ; Meintjes, Graeme ; Rebe, Kevin ; Maartens, Gary Date: 2009 BACKGROUND:High rates of mortality and morbidity have been described in sub-Saharan African patients within the first few months of starting highly active antiretroviral therapy (HAART). There is limited data on the causes of early morbidity ... Read more c b

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