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Browsing by Author "Mayosi, Bongani M"

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A proposal for the eradication of rheumatic fever in our lifetime

Author: Mayosi, Bongani M Date: 2006 The Pan African Society of Cardiology (PASCAR) convened the 1st All Africa Workshop on Rheumatic Fever (RF) and Rheumatic Heart Disease (RHD) on 15 - 16 October 2005 at the Champagne Sports Resort, Drakensberg, South Africa. The purpose of ... Read more
Abnormal diastolic and systolic septal motion following pericardiectomy demonstrated by cine DENSE MRI

Author: Spottiswoode, Bruce ; Russell, James B ; Moosa, Sulaiman ; Meintjes, Ernesta M ; Epstein, Frederick H ; Mayosi, Bongani M Date: 2008 Constrictive pericarditis can lead to paradoxical interventricular septal motion. Displacement encoding with stimulated echoes (DENSE) magnetic resonance imaging (MRI) provides a method for quantifying myocardial motion and strain. A case of ... Read more
African researchers' perceptions and expectations of the benefits of genomics research in Africa : a qualitative study

Author: Munung, Nchangwi Syntia Date: 2016 Introduction: Genomics research raises a number of ethical, legal and social issues (ELSI), one of which is the concept of benefit sharing. While benefits and benefit sharing are difficult to discuss because of questions on what needs to be ... Read more
AFROStrep (SA): a surveillance system for group A streptococcal infection in South Africa

Author: Barth, Dylan Dominic Date: 2018 BACKGROUND AND AIMS OF THE THESIS: Group A β-haemolytic Streptococcus (GAS) also known as Streptococcus pyogenes, is responsible for a wide range of invasive and non-invasive GAS diseases. Prevalence and incidence data on GAS from developing ... Read more
Analysis of genetic variations associated with arrhythmogenic right ventricular cardiomyopathy

Author: Fish, Maryam Date: 2016 Cardiomyopathy accounts for 20-30% of acute heart failure cases in adult Africans. Several types of cardiomyopathy have been identified; this study focused primarily on the genetic causes of arrhythmogenic right ventricular cardiomyopathy ... Read more
Assessing scimitar syndrome - use of MRI and MRA

Author: Dahya, Vijay ; Mayosi, Bongani M Date: 2007 A 36-year-old woman was assessed as a live-related kidney donor. Her chest radiograph showed unsuspected dextroposition of the heart, diminished volumes of the right middle and lower lobes, and a scimitar-shaped shadow extending from the right ... Read more
A candidate gene analysis of arrhythmogenic right ventricular cardiomyopathy (ARVC)

Author: Du Preez, Janine Date: 2006 Heart failure is a major public health problem throughout the world. In South Africa 17% of mortality is attributed to cardiovascular disease (CVD). Heart failure may be either ischemic or non-ischemic in origin. A significant proportion of ... Read more
Cardiac involvement in HIV-infected people living in Africa: A review

Author: Magula, Nombulelo P ; Mayosi, Bongani M Date: 2003 The primary objective of this study was to review and summarise the literature on the spectrum and management of cardiac disease in HIV-infected people living in Africa. We searched MEDLINE (January 1980 to February 2003), reference lists of ... Read more
Cardiomyopathy in Africa: heredity versus environment

Author: Mayosi, Bongani M ; Somers, Krishna Date: 2007 Unlike other parts of the world in which cardiomyopathy is rare, heart muscle disease is endemic in Africa. The major forms of cardiomyopathy in Africa are dilated cardiomyopathy (DCM) and endomyocardial fibrosis (EMF). Whereas DCM is a major ... Read more
Chromosome 16q22 variants in a region associated with cardiovascular phenotypes correlate with ZFHX3 expression in a transcript-specific manner

Author: Martin, Ruairidh I R ; Owens, W A ; Cunnington, Michael S ; Mayosi, Bongani M ; Koref, Mauro S ; Keavney, Bernard D Date: 24 Dec 2014 Background: The ZFHX3 gene, located in Chromosome 16q22.3, codes for a transcription factor which is widely expressed in human tissues. Genome-wide studies have identified associations between variants within the gene and Kawasaki disease and ... Read more c b
Chromosome 9p21 SNPs associated with multiple disease phenotypes correlate with ANRIL expression

Author: Cunnington, Michael S ; Koref, Mauro Santibanez ; Mayosi, Bongani M ; Burn, John ; Keavney, Bernard Date: 2010 Author Summary Genetic variants on chromosome 9p21 have been associated with several important diseases including coronary artery disease, diabetes, and multiple cancers. Most of the risk variants in this region do not alter any protein ... Read more c b
Clinical characteristics, causes, adherence to heart failure treatment guidelines and mortality of patients with acute heart failure: the Groote Schuur Hospital experience

Author: Szymanski, Patryk Zygmunt Date: 2016 Background: There is limited information on acute heart failure (AHF) and the treatment thereof in sub-Saharan Africa. Therefore, the aim of this study was to describe the clinical characteristics, causes, adherence to heart failure (HF) ... Read more
Common variation neighbouring micro-RNA 22 is associated with increased left ventricular mass

Author: Harper, Andrew R ; Mayosi, Bongani M ; Rodriguez, Antony ; Rahman, Thahira ; Hall, Darroch ; Mamasoula, Chrysovalanto ; Avery, Peter J ; Keavney, Bernard D Date: 2013 AIMS: Previous genome-wide linkage analysis has suggested that chromosomal region 17p13.3 may harbour genes influencing left ventricular mass (LVM) in man. To date, the genetic factors accounting for LVM variability remain largely unknown but ... Read more c b
A Cost-Effectiveness Analysis of a Program to Control Rheumatic Fever and Rheumatic Heart Disease in Pinar del Rio, Cuba

Author: Watkins, David A ; Mvundura, Mercy ; Nordet, Porfirio ; Mayosi, Bongani M Date: 2015 BACKGROUND: Acute rheumatic fever (ARF) and rheumatic heart disease (RHD) persist in many low- and middle-income countries. To date, the cost-effectiveness of population-based, combined primary and secondary prevention strategies has not been ... Read more c b
Developing the African national health research systems barometer

Author: Kirigia, Joses M ; Ota, Martin O ; Senkubuge, Flavia ; Wiysonge, Charles S ; Mayosi, Bongani M Date: 22 Jul 2016 Background: A functional national health research system (NHRS) is crucial in strengthening a country’s health system to promote, restore and maintain the health status of its population. Progress towards the goal of universal health coverage ... Read more c b
Dextrocardia with anterior myocardial infarction: images in cardiology

Author: Cocciante, Adriano G ; Mayosi, Bongani M ; Stevens, John E Date: 2003 A 56-year-old female smoker presented to hospital with the sudden onset of chest tightness and dyspnoea, lasting for 4 hours. Clinical and radiological examination revealed dextrocardia and situs inversus. The admission ECG, performed with ... Read more
Diagnostic accuracy of quantitative PCR (Xpert MTB/RIF) for tuberculous pericarditis compared to adenosine deaminase and unstimulated interferon-γ in a high burden setting: a prospective study

Author: Pandie, Shaheen ; Peter, Jonathan G ; Kerbelker, Zita S ; Meldau, Richard ; Theron, Grant ; Govender, Ureshnie ; Ntsekhe, Mpiko ; Dheda, Keertan ; Mayosi, Bongani M Date: 18 Jun 2014 Background: Tuberculous pericarditis (TBP) is associated with high morbidity and mortality, and is an important treatable cause of heart failure in developing countries. Tuberculous aetiology of pericarditis is difficult to diagnose promptly. ... Read more
Effect of distance to health facility on the maintenance of INR therapeutic ranges in rheumatic heart disease patients from Cape Town: No evidence for an association

Author: Barth, Dylan Dominic ; Zühlke, Liesl ; Joachim, Alexia ; Hoegger, Tyler ; Mayosi, Bongani M ; Engel, Mark E Date: 01 Jun 2015 Background: Lack of adherence to international normalised ratio (INR) monitoring in rheumatic heart disease (RHD) patients is a contributor to cardio-embolic complications. This population-based observational study investigated whether the ... Read more c b
The Effects of Angiotensin Converting Enzyme Inhibitors (ACE-I) on Human N-Acetyl-Seryl-Aspartyl-Lysyl-Proline (Ac-SDKP) Levels: A Systematic Review and Meta-Analysis

Author: Mnguni, Ayanda Trevor ; Engel, Mark E ; Borkum, Megan S ; Mayosi, Bongani M Date: 2015 BACKGROUND: Tuberculous pericardial effusion is a pro-fibrotic condition that is complicated by constrictive pericarditis in 4% to 8% of cases. N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) is a ubiquitous tetrapeptide with anti-fibrotic ... Read more c b
The effects of angiotensin converting enzyme inhibitors (ACEI) on human N-acetylseryl-aspartyl-lysyl-proline (AcSDKP) levels : a systematic review

Author: Mnguni, Ayanda Trevor Date: 2015 Background: Tuberculous pericardial effusion is a pro-fibrotic condition that is complicated by constrictive pericarditis in 4-8% of cases. N-acetyl-seryl-aspartyl-lysylproline (Ac-SDKP) is a ubiquitous tetrapeptide with antifibrotic properties ... Read more

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