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Browsing by Author "Lecour, Sandrine"

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Biomarkers of ventricular remodelling in African hypertensives.

Author: Dike, Ojji Date: 2013 There is substantial evidence that the burden of hypertension, hypertension with left ventricular hypertrophy and hypertensive heart failure is very enormous in sub-Saharan Africa. There is therefore the need to look for easier and faster ... Read more
Cardioprotective role of signal transducer activator of transcription 3 (STAT-3) against ischaemai reperfusion injuries

Author: King, Jonathan Chan Date: 2011 Introduction: Sphingosine 1 phosphate (S1P) is a major constituent of high density lipoprotein (HDL) cholesterol. Both S1P preconditioning and ischaemic postconditioning reduce myocardial damage following an ischaemia-reperfusion insult but ... Read more
Characterisation of cardiac remodeling associated with pregnancy: providing insights to peripartum cardiomyopathy

Author: Kodogo, Vitaris Date: 2021 Introduction: Maternal cardiovascular changes that occur in pregnant women are usually well tolerated by most women experiencing an uncomplicated pregnancy and are reversable postpartum. However, pregnancy can induce adverse cardiac events ... Read more
Delineation of the Cardioprotective Agents found in red wine

Author: Lamont, Kim Date: 2009 Secondary leach concentrate (SLC) is an important bleed stream for minor elements from Anglo Platinum's Base Metal Refinery (BMR) which produces copper nickel and cobalt sulphate. It contains mainly sulphur, iron jarosites, unleached base ... Read more
Exercise intervention alters HDL subclass distribution and function in obese women

Author: Woudberg, Nicholas J ; Mendham, Amy E ; Katz, Arieh A ; Goedecke, Julia H ; Lecour, Sandrine Date: 10 Oct 2018 Background Obesity is associated with a change in high-density lipoprotein (HDL) function and subclass. Exercise training reduces cardiovascular risk in obese patients. We aimed to explore the effect of an exercise training ... Read more
Exploring the cardioprotective effect of synthetic wine in Long Evans rats

Author: Dlamini, Lindizwe Date: 2015 [No copyright notice] Background: Moderate and chronic consumption of red wine protects against cardiovascular disease. Wine is a complex matrix containing multiple molecules whose concentrations can vary from one bottle to another. Therefore, ... Read more
Investigating high-density lipoprotein (HDL) subfractions, composition and functionality in people living with HIV

Author: Hudson, Peter Date: 2022 Background: Although antiretroviral therapy (ART) increases survival in individuals living with human immunodeficiency virus (HIV), this population faces an increased risk for cardiovascular disease (CVD). There is mounting evidence that the ... Read more
Investigating the possible cytoprotective effects of melatonin isomer against simulated ischemic injury

Author: Victor, Laikyn Date: 2017 Introduction: The presence of melatonin in wine contributes to the cardioprotective effect of regular and moderate consumption of wine against lethal ischemia/reperfusion injury. Recently, the presence of melatonin isomers has been identified ... Read more
Melatonin as a novel cardioprotective therapy in pulmonary hypertension

Author: Maarman, Gerald Jerome Date: 2014 Pulmonary hypertension (PH) is characterized by elevated pulmonary arterial pressure which leads to right ventricular hypertrophy and failure. The mechanism involved in the pathophysiology of the disease remains unclear but it is suggested ... Read more
The role of melatonin in peripartum cardiomyopathy

Author: Nicholson, Lauren Date: 2013 Peripartum cardiomyopathy (PPCM) is a heart disease of unknown aetiology emerging in previously healthy women towards the end of pregnancy or first postpartum months. Previous studies have suggested that oxidative stress contributes to the ... Read more
The role of melatonin in red wine-induced cardioprotection

Author: Lamont, Kim Date: 2012 Several epidemiological studies have suggested that the regular moderate consumption of red wine confers cardioprotection. However, the exact components in red wine that confer this effect are unclear. Previous studies performed in our ... Read more
Role of nuclear factors kappa-B in TNFα-induced cytoprotection

Author: Somers, Sarin J Date: 2006 Includes bibliographical references (leaves 67-81). Read more
The role of signal transducer and activator of transcription-3 (STAT-3) in ischaemic and pharmacological postconditioning

Author: Somers, Sarin J Date: 2011 Includes abstract. Includes bibliographical references (leaves 131-147). Read more
Role of the SAFE pathway and the mitochondria in HDL cholesterol (and its constituent sphingosine-1-phosphate) induced cardioprotection

Author: Hacking, Damian Date: 2011 High density lipoprotein cholesterol (HDL) and its component sphingosine-1-phosphate (S1P) protect against myocardial infarction. Recently, the SAFE (survivor activating factor enhancement) pathway, involving tumour necrosis factor (TNF) and ... Read more
The role of Toll-like receptor 4 (TLR-4) in wine-induced cardioprotection

Author: Albertyn, Zulfah Date: 2012 Moderate and chronic consumption of red wine confers cardioprotection. Melatonin, present in wine, may contribute to this cardioprotective effect. Melatonin confers cardioprotection via the activation of tumor necrosis factoralpha (TNF-α) ... Read more
Role of Tumour Necrosis Factor Alpha (TNFa) in ischaemic and pharmacological postconditioning

Author: Lacerda, Lydia Date: 2010 Ischaemic postconditioning (IPostC) is a powerful protective mechanism that activates prosurvival intrinsic signalling cascades to limit reperfusion injury but the exact signalling pathway involved in this cardioprotective effect still remains ... Read more
Signalling pathways involved in TNFα-induced cytoprotection : role of reactive oxygen species

Author: Lacerda, Lydia Date: 2005 Tumour necrosis factor alpha (TNFa) is a pleiotropic cytokine which has both beneficial and deleterious effects. It has previously been shown in our laboratory that TNFa can mimic ischemic preconditioning (IPC). However, the signalling pathways ... Read more
Targeting heart rate as a novel therapeutic approach in acute heart failure

Author: Imamdin, Aqeela Date: 2018 Background and hypothesis: Standard pharmacological treatment for heart failure improves cardiac remodelling and survival in the setting of chronic heart failure, but is suboptimal in cases of acute heart failure (AHF). Peripartum cardiomyopathy ... Read more
Testing metabolic and pharmacological agents for recovery following de novo acute heart failure in an isolated rat heart model

Author: Deshpande, Gaurang Date: 2014 Acute heart failure is a potentially lethal clinical emergency without any effective therapy. Using an isolated rat heart model, we established and validated a model of de novo acute heart failure to study novel putative cardio protective ... Read more
Understanding the relationship between high-density lipoprotein (HDL) subclass distribution and functionality in patients at risk of cardiovascular disease

Author: Woudberg, Nicholas Date: 2017 Background: Risk factors for cardiovascular disease (CVD) include obesity, ethnicity and hypertension. High-density lipoprotein (HDL) has traditionally served as a marker for CVD risk. Latest studies, however, propose that the composition and ... Read more

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