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Browsing by Author "Horn, Neil"

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A retrospective observational study of the effectiveness of long acting antipsychotic injectable on hospital admissions

Author: Charles, Bhaskaran Nathamaniar Date: 2018 Background: The impact on hospitalisations/ relapse rates of utilising long-acting antipsychotic injectable (LAIs) in a South African population suffering from chronic psychotic spectrum mental illness is poorly researched. Aim: To compare ... Read more
A retrospective study of outcomes after referral to the early intervention in psychosis programme at Valkenberg Psychiatric Hospital

Author: Setjie, Sewela ; ; Date: 2023 Background. Psychotic Disorders affect more than 1% of the South African adult population and have a chronic course that is associated with high rates of morbidity and mortality. The implementation of early intervention strategies may reduce ... Read more
Effects of bipolar disorder on intrinsic brain networks

Author: Starke, Jonathan Alan Date: 2016 Introduction: Bipolar disorder (BD) is a brain network disorder that affects cognitive and emotional functioning, and is associated with prefrontal and/or limbic dysfunction. Functional Magnetic Resonance Imaging (fMRI) allows identification ... Read more
The genetics of lithium-induced adverse drug reactions in bipolar disorder patients : a pilot study

Author: Weideman, Reinette Date: 2013 Lithium is regarded as the first-line pharmacotherapy for the treatment of acute mood episodes, suicide prevention and prophylactic treatment in patients with bipolar disorder (BPD). Response to lithium has a strong genetic component and ... Read more
Mindfulness based cognitive therapy improves frontal control in bipolar disorder: a pilot EEG study

Author: Howells, Fleur ; Ives-Deliperi, Victoria ; Horn, Neil ; Stein, Dan Date: 2012 BACKGROUND: Cognitive processing in Bipolar Disorder is characterized by a number of attentional abnormalities. Mindfulness Based Cognitive Therapy combines mindfulness meditation, a form of attentional training, along with aspects of cognitive ... Read more c b
Psychosis and relapse in bipolar disorder are related to GRM3 DAOA and GRIN2B genotype

Author: Dalvie, S ; Horn, Neil ; Nossek, Christel ; van der Merwe, L ; Stein, Dan ; Ramesar, Raj Date: 2010 Objective: Dysfunction in glutamate signalling is thought to play a role in the pathophysiology of bipolar disorder (BD). There is evidence of associations between single nucleotide polymorphisms (SNPs) in GRM3, GRIN2B, and DAOA genes and the ... Read more
A systematic review of DTI studies in Bipolar Disorder

Author: Nortje, Gareth Date: 2012 In the last decade, multiple diffusion tensor imaging (DTI) studies have revealed changes in the microstructure of white matter in bipolar disorder. The results are poorly replicated and inconsistent, however, with some authors suggesting a ... Read more
Systematic review of imaging studies in the lateral orbitofrontal circuit in bipolar type I disorder

Author: Yorke, Neil Date: 2013 The aim of this study was to review the available published structural magnetic resonance imaging (MRI) data in bipolar type I disorder, looking for any evidence of a change in size of the structures in lateral orbitofrontal circuits relative ... Read more

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