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Browsing by Author "Eley, Brian"

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A retrospective description of primary immunodeficiency diseases at Red Cross War Memorial Children's Hospital, Cape Town, South Africa, 1975 – 2017

Author: Moodley, Sashmi Date: 2020 Background. The primary immunodeficiency diseases (PIDs) constitute a diverse and everexpanding group of inborn errors affecting a wide range of immune functions. They are not well documented in Sub-Saharan Africa. An important barrier to ... Read more
A retrospective description of primary immunodeficiency diseases at Red Cross War Memorial Children's Hospital, Cape Town, South Africa, 1975 – 2017

Author: Moodley, Sashmi Date: 2020 Background. The primary immunodeficiency diseases (PIDs) constitute a diverse and everexpanding group of inborn errors affecting a wide range of immune functions. They are not well documented in Sub-Saharan Africa. An important barrier to ... Read more
A ten-year review of ESBL and non-ESBL Escherichia Coli Bloodstream infections among children at a tertiary referral hospital in South Africa

Author: Malande, Oliver Ombeva Date: 2019 Introduction: Bloodstream infection (BSI) is an important cause of morbidity and mortality in children (1). There are few descriptions of Escherichia coli (E. coli) BSI in children, particularly in Africa, yet E. coli is increasing in importance ... Read more
Adherence to antiretroviral therapy in young children in Cape Town, South Africa, measured by medication return and caregiver self-report : a prospective cohort study

Author: Davies, Mary-Ann Date: 2010 Excellent adherence to antiretroviral therapy (ART) is necessary if HIV-infected children are to experience the dramatically improved outcomes that this treatment affords. However, there is very limited data on adherence to antiretroviral ... Read more
Adherence to antiretroviral therapy in young children in Cape Town, South Africa, measured by medication return and caregiver self-report: a prospective cohort study

Author: Davies, Mary-Ann ; Boulle, Andrew ; Fakir, Tanzeem ; Nuttall, James ; Eley, Brian Date: 2008 BACKGROUND:Antiretroviral therapy (ART) dramatically improves outcomes for children in Africa; however excellent adherence is required for treatment success. This study describes the utility of different measures of adherence in detecting ... Read more c b
Antiretroviral treatment for children

Author: Eley, Brian ; Davies, Mary-Ann ; Apolles, Patti ; Cowburn, Carol ; Buys, Heloise ; Zampoli, Marco ; Finlayson, Heather ; King, Spasina ; Nuttall, James Date: 2006 Objective: To describe the response of children during their first year on highly active antiretroviral therapy (HAART). Design: Retrospective, descriptive. Setting. Tertiary, referral hospital. Subjects: All HIV-infected children commenced ... Read more
Aspect of tuberculosis case management at Red Cross Children's Hospital

Author: Moore, David Paul Date: 2010 Aim: To describe the spectrum of tuberculosis in children <15 years of age attending Red Cross War Memorial Children's Hospital between January 2006 and December 2008. Methods: A retrospective review of a paper-based Notifications Register ... Read more
Blood stream infections in oncology patients at Red Cross War Memorial Children's Hospital, Cape Town

Author: Mvalo, Tisungane Knox Titus Date: 2017 Background: Infections cause significant morbidity and mortality in children with cancer, which may be related to the cancer or treatment received. There is paucity of data on the epidemiology of bloodstream infection (BSI) in sub-Saharan ... Read more
Bloodstream infections at a tertiary level paediatric hospital in South Africa

Author: Lochan, Harsha ; Pillay, Vashini ; Bamford, Colleen ; Nuttall, James ; Eley, Brian Date: 06 Dec 2017 Background: Bloodstream infection (BSI) in children causes significant morbidity and mortality. There are few studies describing the epidemiology of BSI in South African children. Methods: A retrospective descriptive cohort study was conducted ... Read more
Candida bloodstream infection among children hospitalized in three public sector hospitals in the Metro West region of Cape Town, South Africa

Author: Gebremicael, Mulugeta Naizgi Date: 2022 Introduction Candida bloodstream infection (BSI) causes appreciable mortality in children. There are few studies describing the epidemiology of Candida BSI in children living in the Western Cape province of South Africa. Methods A retrospective ... Read more
The clinical and molecular spectrum of galactosemia in patients from the Cape Town region of South Africa

Author: Henderson, Howard ; Leisegang, Felicity ; Brown, Ruth ; Eley, Brian Date: 2002 BACKGROUND:The objective of this study was to document the clinical, laboratory and genetic features of galactosemia in patients from the Cape Town metropolitan region. METHODS: Diagnoses were based on thin layer chromatography for ... Read more c b
Colonisation with extended spectrum beta-lactamase producing and carbapenem-resistant enterobacterales in children admitted to a paediatric referral hospital in South Africa

Author: Ogunbosi, Babatunde Oluwatosin Date: 2020 Introduction: There are few studies describing colonisation with extended spectrum beta-lactamase-producing Enterobacterales (ESBL-PE) and carbapenem-resistant Enterobacterales (CRE) among children in subSaharan Africa. Colonisation often ... Read more
Culture-confirmed childhood tuberculosis in Cape Town, South Africa: a review of 596 cases

Author: Schaaf, H Simon ; Marais, Ben ; Whitelaw, Andrew ; Hesseling, Anneke ; Eley, Brian ; Hussey, Gregory ; Donald, Peter Date: 2007 BACKGROUND:The clinical, radiological and microbiological features of culture-confirmed childhood tuberculosis diagnosed at two referral hospitals are described. METHODS: Cultures of Mycobacterium tuberculosis from children less than 13 years ... Read more c b
Epidemiology of Staphylococcus aureus bacteraemia at a tertiary children's hospital in Cape Town, South Africa

Author: Naidoo, Reené Date: 2012 Includes abstract. Includes bibliographical references. Read more
Epidemiology of Staphylococcus aureus bacteraemia at a tertiary children's hospital in Cape Town, South Africa

Author: Naidoo, Reené ; Nuttall, James ; Whitelaw, Andrew ; Eley, Brian Date: 2013 BACKGROUND: Staphylococcus aureus is an important pathogen in paediatric patients with bloodstream infections. The epidemiology of S. aureus bacteraemia, however, has not been well documented in children in South Africa. METHODS: A retrospective ... Read more c b
Growth of luciferase-transfected BCG in whole blood : use of a novel assay to study immune responses to mycobacteria in children

Author: Tena, Nontobeko Gwendoline Date: 2003 The existing Bacille Calmette-Guerin (BCG) vaccine offers some protection against TB, but its efficacy varies for unknown reasons. In order to develop an effective vaccine, a comprehensive understanding of protective immunity in adults and ... Read more
Guidelines for the management of HIV-infected children (National Department of Health, South Africa, 2005): A summary of antiretroviral treatment guidelines

Author: Meyers, Tammy ; Eley, Brian Date: 2005 National guidelines for the management of HIV-infected children in South Africa have been developed as a consensus document by practising HIV clinicians around the country. Guidelines for antiretroviral (ARV) management of children appear in ... Read more
HIV Encephalopathy: pediatric case series description and insights from the clinic coalface

Author: Donald, Kirsten A ; Walker, Kathleen G ; Kilborn, Tracy ; Carrara, Henri ; Langerak, Nelleke G ; Eley, Brian ; Wilmshurst, Jo M Date: 17 Jan 2015 Background: The Human Immune Deficiency Virus (HIV) can manifest neurologically in both adults and children. Early invasion of the central nervous system by the virus, affecting the developing brain, is believed to result in the most common ... Read more c b
HIV-infected infants born to women who tested HIV-negative during pregnancy

Author: Nuttall, James ; Eley, Brian ; Honikman, Simone Date: 2004 The prevention of mother-to-child transmission (PMTCT) programme in the Western Cape is said to have achieved 100% coverage.1 This implies that all pregnant women who attend an antenatal health care facility in the public sector are offered ... Read more
The impact of HIV infection on the nervous system of children

Author: Eley, Brian ; Wilmshurst, Jo Date: 23 Sep 2008 At the end of 2007, 33.2 million people including 2.5 million children were living with HIV; > 85% of HIV-infected children were in Africa. At the end of 2006, 115 000 children were on HAART, a global coverage rate of 15% with sub-Saharan ... Read more c b

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