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Browsing by Author "Collins, Malcolm"

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The association of the AVPR2 gene with serum sodium and water imbalances during an Ironman Triathlon

Author: Ah Kun, Maresa Date: 2007 It is well documented that participation in ultra-endurance events such as the Ironman Triathlon, can be associated with the development of post-race water and sodium imbalances in athletes. Variants within genes that encode for proteins that ... Read more
Characterisation of the 3'-UTR of the COL5A1 gene: implication for musculoskeletal soft tissue injuries

Author: Laguette, Mary-Jessica Nancy Date: 2015 COL5A1 encodes the α1 chain of type V collagen, a minor fibrillar collagen that is an important regulator of collagen fibril assembly. A polymorphism (rs12722, C/T) within the 3'-untranslated region (UTR) of COL5A1 is associated with chronic ... Read more
A comparison of two treatment protocols in the management of exercise-associated postural hypotension (EAPH) : a randomised clinical trial

Author: Anley, Cameron Date: 2007 The aim of this study was to compare which of the two commonly used treatment protocols for Exercise Associated Postural Hypotension (EAPH) (Trendelenburg with oral fluids ad libitum or intravenous fluids) result in quicker recovery and earlier ... Read more
Concussion-Associated Polygenic Profiles of Elite Male Rugby Athletes

Author: Antrobus, Mark R ; Brazier, Jon ; Callus, Peter C ; Herbert, Adam J ; Stebbings, Georgina K ; Khanal, Praval ; Day, Stephen H ; Kilduff, Liam P ; Bennett, Mark A ; Erskine, Robert M ; Raleigh, Stuart M ; Collins, Malcolm ; Pitsiladis, Yannis P ; Heffernan, Shane M ; Williams, Alun G Date: 04 May 2022 Due to the high-velocity collision-based nature of elite rugby league and union, the risk of sustaining a concussion is high. Occurrence of and outcomes following a concussion are probably affected by the interaction of multiple genes in a ... Read more c b
Dietary fat modulates the relationship between polymorphisms in the TNFA and IL-6 genes, and obesity and serum lipid concentrations in black and white South Afican women

Author: Joffe, Yael Date: 2013 The primary aim of the thesis was to investigate associations between TNFA (TNFA-308 G>A and -238 G>A) and IL-6 (-174 G>C, IVS3+281 G>T, IVS4+869 A>G) sequence variants and obesity and serum lipid concentrations in black and white SA women. ... Read more
The effect of chronic exposure to endurance exercise on the skeletal muscle of distance runners

Author: Rae, Dale Elizabeth Date: 2007 It is likely that masters runners may experience an intolerance to exercise primarily due to the age-related changes in their bodies, and specifically of those systems and organs most utilised during running. A more disturbing phenomenon, ... Read more
Effects of elevated plasma adrenaline levels on substrate metabolism, effort perception and muscle activation during low-to-moderate intensity exercise

Author: West, Sacha J ; Goedecke, Julia H ; Van Niekerk, Lizl ; Collins, Malcolm ; St Clair Gibson, Alan ; MacDonald, Ian A ; Noakes, Timothy D ; Lambert, Estelle V Date: 2005 The aim of this study was to differentiate the role of raised plasma adrenaline (Adr) concentrations from sympathoadrenal activation associated with moderate-intensity exercise, on muscle activation, cardiopulmonary responses, fuel metabolism, ... Read more
Endurance performance : the integrative physiology of resisting fatigue

Author: Harley, Yolande Xanthe Rocille Date: 2004 Includes bibliographical references. Read more
Exercise-associated muscle cramping (EAMC) in Ironman triathletes

Author: Drew, Nichola Date: 2006 Exercise-associated muscle cramping (EAMC) is a common condition of spontaneous, painful skeletal muscle spasms that occur in exercising muscles during exercise or in the immediate post-exercise period. There is a high prevalence in endurance ... Read more
Exercise-induced protection against insulin resistance and type 11 diabetes : the role of calcium

Author: Smith, James Antony Harris Date: 2008 Regular exercise protects individuals against developing insulin resistance and type II diabetes. This effect of exercise does not appear to be due to an improvement in the insulin signalling pathway but instead due to an increase in the ... Read more
Extracellular matrix gene sequence variant analyses and Achilles tendinopathy

Author: Saunders, Colleen Jayne Date: 2013 The primary aim of this thesis was to identify additional genetic elements predisposing individuals to risk of AT using a candidate gene, case-control genetic association approach, and to propose the biological mechanisms underlying this ... Read more
Gastrointestinal tract (GIT) symptons in Ironman triathletes : a study relating GIT symptons to changes in splanchnic blood flow

Author: Wright, Helen Date: 2008 Gastrointestinal tract (GIT) symptoms commonly affect endurance athletes such as those competing in the Ironman Triathlon. Although a number of risk factors and the pathophysiological mechanisms for the development of GIT symptoms during ... Read more
Genetic factors associated with performance and exercise-associated weight loss in Ironman triathletes

Author: De Milander, Liesl Date: 2012 The aim of this thesis was to investigate candidate genes, mainly within the CNS, that may contribute to the variation in physiological responses (body weight changes) and athletic ability between athletes during participation in a 226 km ... Read more
Genetic risk factors for anterior cruciate ligament ruptures

Author: Posthumus, Michael Date: 2009 The primary aim of this thesis was to identify candidate genes that may be associated with ACL ruptures, and then use a genetic association approach following a case-control study design to identify specific sequence variants (single nucleotide ... Read more
Genetic risk factors for carpal tunnel syndrome

Author: Burger, Marilize Cornelle Date: 2014 Carpal tunnel syndrome (CTS) is a common occupational injury that is caused by an increase in pressure within the carpal tunnel structure which, in turn, causes compression of the median nerve. Although several factors are believed to be ... Read more
The impact of body fat and its distribution on risk factors for cardiovascular disease in black South African women

Author: Jennings, Courtney L Date: 2008 Obesity and obesity-related diseases are a large global problem in both developed and developing nations. In South Africa, a country currently undergoing epidemiological transition, the prevalence of obesity is high, particularly in urban ... Read more
Intrinsic and extrinsic factors associated with change in range of motion (ROM) after a single stretch session and repeated loading following an endurance run

Author: Miller, Caron-Jayne Date: 2011 Static stretching is commonly performed by athletes and clinicians on the assumption that it increases joint range of motion (ROM). However, observations from our laboratory indicate that there is an apparent inter-individual variance in the ... Read more
Intrinsic and extrinsic factors associated with range of motion (ROM) with an emphasis on a novel genetic factor

Author: Brown, James Craig Date: 2010 Introduction: Although there are numerous health benefits associated with participating in regular physical activity, there is also an increased risk of sustaining injuries, in particular musculoskeletal soft tissue injuries. Both an increased ... Read more
An investigation of DNA sequence variants in genes that regulate collagen fibrillogenesis and predisposition to musculoskeletal soft tissue injuries

Author: Hay, Melanie Date: 2013 The aim of this dissertation was to use a case-control genetic study to investigate the association of polymorphisms within the COL5A1, MIR608, COL11A1 and COL11A2, genes with AT and/or ACL injuries in Caucasian populations. These aims were ... Read more
Investigation of selected collagen genes in exercise-related musculoskeletal soft tissue phenotypes

Author: O’Connell, Kevin Sean Date: 2014 Previous findings have suggested that functional variants within collagen encoding genes are associated with several musculoskeletal soft tissue injuries and other exercise-related phenotypes. Specifically variants within the functional COL5A1 ... Read more

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