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Browsing by Author "Caira, Mino R"

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Anti-cancer and anti-malarial 4-aminoquinoline derivatives : synthesis and solid-state investigations

Author: Melo, Candice Soares de Date: 2006 The work presented in this thesis is two-fold: (i) development of single agents that provide inhibition of both the growth of malaria parasites and of tumour cells in vitro, and (ii) inclusion of these potential novel inhibitors in cyclodextrin ... Read more
Antimycobacterial 2-aminoquinazolinones and benzoxazole-based oximes: synthesis, biological evaluation, physicochemical profiling and supramolecular derivatization

Author: Njaria, Paul Magutu Date: 2017 Tuberculosis (TB) is a life-threatening infectious disease caused by Mycobacterium tuberculosis (Mtb). Globally, TB is a major public health burden with an estimated 10.4 million new cases and 1.8 million deaths reported in 2015. Although TB ... Read more
Beneficiation of selected pesticides and an antihyperlipidemic agent via cyclodextrin complexation and co-crystallization

Author: Maurel, Vaughan Jean Date: 2016 The applications of many bioactive molecules are limited by their undesirable physicochemical properties, such as poor aqueous solubility and low thermal stability. The agrochemicals methyl- 2,5-dichlorobenzoate (fungicide, DCB) and fenthion ... Read more
Complexation between cyclodextrins and phenylurea herbicides in solution and in the solid state

Author: Smith, Vincent Joseph Date: 2009 The author undertook the preparation of cyclodextrin inclusion complexes of four phenylurea herbicides (metobromuron, monolinuron, monuron and fenuron) using the kneading and co-precipitation methods in the solid state while also determining ... Read more
The crystal and molecular structures of some bioinorganic compounds

Author: Caira, Mino R Date: 1975 In this thesis are presented the results of X-ray structural studies of seven metal-containing crystalline compounds. In some cases, the ligands associated with the metals are themselves biologically active; in other cases, the compound as ... Read more
Crystal isostructurality and X-ray diffraction studies of cyclodextrin inclusion compounds

Author: Lubhelwana, Siyanda Date: 2005 The first part of this dissertation is an update on the isostructurality method of PXRD analysis (lsoPXRD), the last update having been published in 2001 The scope of the isostructurality part of this dissertation includes organic inclusion ... Read more
The crystal structure of the Adduct [VO(ACA)₂.4-Phenylpyridine]

Author: Caira, Mino R Date: 1971 Read more
Crystallization of two forms of a cyclodextrin inclusion complex containing a common organic guest

Author: Caira, Mino R ; De Vries, Elise J C ; Nassimbeni, Luigi R Date: 2003 The isolation and structural elucidation by single crystal Xray diffraction of triclinic and monoclinic modifications of an inclusion complex of b-cyclodextrin with the same guest, methylparaben, are reported. Read more
Enhancing the helical distortion in pyrrolo[1,2-a]phenanthrolines

Author: Dumitraşcu, Florea ; Caira, Mino R ; Drăghici, Constantin ; Căproiu, Miron Teodor ; Barbu, Loredana ; Dumitrescu, Dan G Date: 2010 The International Society for Burns Injuries (ISBI) has published guidelines for the management of multiple or mass burns casualties, and recommends that 'each country has or should have a disaster planning system that addresses its own ... Read more
Fluorescent ajoenes as a mechanistic probe for cancer

Author: Cotton, Jonathan Date: 2010 This thesis describes the development and synthesis of several novel ajoene mimics. The first of which, (E/Z)-1,8-(Bis-p-methoxyphenyl)-2,3,7-trithia-octa-4-ene 7-oxide 17, was developed as a continuation of SAR studies performed by our group, ... Read more
Inclusion of alkylparabens in cyclodextrins

Author: De Vries, Elise Janine Christl Date: 2003 The aim of this thesis was to prepare crystalline inclusion complexes with cyclodextrins (CDs), as hosts, and drugs, as guests, characterise them using various methods and attempt to elucidate their structures by X-ray diffraction methods to ... Read more
New crystalline forms of permethylated β-cyclodextrin

Author: Caira, Mino R ; Bourne, Susan A ; Mhlongo, Welcome T ; Dean, Pamela M Date: 2004 Two new crystalline forms of permethylated β-cyclodextrin are reported that contain methylglucose residues exclusively in the 4C1 conformation, in contrast to the known monohydrate, in which a single methylglucose residue adopts the 1C4 conformation. Read more
New tri- and tetra-substituted pyrroles via quinazolinium N1-ylides

Author: Caira, Mino R ; Georgescu, Emilian ; Barbu, Loredana ; Georgescu, Florentina ; Dumitraşcu, Florea Date: 2011 New tri-and tetra-substituted N-arylpyrroles were synthesized by one-pot reaction of 3,7-disubstituted quinazolinonium bromides with substituted alkynes having at least one electron-withdrawing substituent in 1,2-epoxybutane acting both as ... Read more
The optical resolution of albuterol

Author: Stevens, Anne Theresa Date: 1998 The acetonide derivative of (rac)-albuterol has been prepared and used as a substrate in cocrystallisation experiments with several acidic resolving agents~ Successful resolution of the acetonide was achieved with both di-0-benzoyl- and ... Read more
Physicochemical characterisation of cyclodextrin-drug complexes

Author: Griffith, Vivienne Jean Date: 1996 The cyclodextrins and their derivatives are finding increasing application in the pharmaceutical industry as carrier molecules for many drugs, as complexation can result in improved physical characteristics such as increased aqueous solubility ... Read more
Physicochemical studies of the inclusion of selected agrochemicals in cyclodextrins

Author: Cruickshank, Dyanne Louise Date: 2011 Pesticides frequently display adverse properties such as low aqueous solubility, low stability, and high toxicity that limit their applications and render them environmentally hazardous. The possibility of improving these physical properties ... Read more
Physicochemical study of inclusion of drug molecules in cyclodextrins

Author: Dodds, Devric Reginald Date: 1999 Inclusion of drug molecules in cyclodextrins can significantly improve various aspects of their performance and has resulted in the use of cyclodextrins (CDs) for a wide variety of pharmaceutical applications. Consequently, the cyclodextrin ... Read more
Physicochemical study of solid Cyclodextrin inclusion complexes of the antithrombotic Ajoene

Author: Smith, Vincent Joseph Date: 2004 This study describes the preparation and physicochemical characterization of inclusion complexes formed between selected cyclodextrins (CDs) and ajoene, an antlthrombotlc found in garlic. The E and Z isomers of ajoene (4,5,9,-trithiadodeca- ... Read more
The physio-chemical properties of organic inclusion compounds

Author: Le Roex, Tanya Date: 2004 In this thesis the inclusion properties of the host compounds trans-9,10-dihydroxy-9,10-bis(p-tert-butylphenyl)-9, 10-dihydroanthracene (TBDDDA), 9.9'-(Biphenyl-4,4'diyl) difluoren-9-ol (WEB24) and 1â ´ ,1â ¶,5â ´,5â ¶-tetrahydroxy-2,4,6,8- ... Read more
Polymorphs, cyclodextrin inclusion complexes and salts of the bronchodilator tulobuterol

Author: Oliver, Clive Lloyd Date: 2004 The aim of this thesis was to prepare polymorphs, cyclodextrin inclusion complexes and salts of tulobuterol, a drug with bronchodilating properties. Polymorphic drugs are of interest to the pharmaceutical industry because of their varied ... Read more

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