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Browsing by Author "Badri, Motasim"

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Clinical diagnostic utility of IP-10 and LAM antigen levels for the diagnosis of tuberculous pleural effusions in a high burden setting

Author: Dheda, Keertan ; Van-Zyl Smit, Richard N ; Sechi, Leonardo A ; Badri, Motasim ; Meldau, Richard ; Symons, Gregory ; Khalfey, Hoosein ; Carr, Igshaan ; Maredza, Alice ; Dawson, Rodney Date: 2009 BACKGROUND: Current tools for the diagnosis of tuberculosis pleural effusions are sub-optimal. Data about the value of new diagnostic technologies are limited, particularly, in high burden settings. Preliminary case control studies have ... Read more c b
Clinical utility of a commercial LAM-ELISA assay for TB diagnosis in HIV-infected patients using urine and sputum samples

Author: Dheda, Keertan ; Davids, Virginia ; Lenders, Laura ; Roberts, Teri ; Meldau, Richard ; Ling, Daphne ; Brunet, Laurence ; Smit, Richard van Zyl ; Peter, Jonathan ; Green, Clare ; Badri, Motasim ; Sechi, Leonardo ; Sharma, Surendra ; Hoelscher, Michael ; Dawson, Rodney Date: 2010 BACKGROUND: The accurate diagnosis of TB in HIV-infected patients, particularly with advanced immunosuppression, is difficult. Recent studies indicate that a lipoarabinomannan (LAM) assay (Clearview-TB®-ELISA) may have some utility for the ... Read more c b
Cost-effectiveness of highly active antiretroviral therapy in South Africa

Author: Badri, Motasim ; Maartens, Gary ; Mandalia, Sundhiya ; Bekker, Linda-Gail ; Penrod, John R ; Platt, Robert W ; Wood, Robin ; Beck, Eduard J Date: 2005 Healthcare costs for HIV-infected South African adults on HAART compared with costs for HIV-infected controls not on HAART. Authors conclude HAART is cost effective. Read more c b
Different screening strategies (single or dual) for the diagnosis of suspected latent tuberculosis: a cost effectiveness analysis

Author: Pooran, Anil ; Booth, Helen ; Miller, Robert F ; Scott, Geoff ; Badri, Motasim ; Huggett, Jim F ; Rook, Graham ; Zumla, Alimuddin ; Dheda, Keertan Date: 2010 BACKGROUND: Previous health economic studies recommend either a dual screening strategy [tuberculin skin test (TST) followed by interferon-gamma-release assay (IGRA)] or a single one [IGRA only] for latent tuberculosis infection (LTBI), the ... Read more c b
Drug-associated adverse events and their relationship with outcomes in patients receiving treatment for extensively drug-resistant tuberculosis in South Africa

Author: Shean, Karen ; Streicher, Elizabeth ; Pieterson, Elize ; Symons, Greg ; van Zyl Smit, Richard ; Theron, Grant ; Lehloenya, Rannakoe ; Padanilam, Xavier ; Wilcox, Paul ; Victor, Tommie C ; van Helden Paul ; Groubusch Martin ; Warren, Robin ; Badri, Motasim ; Dheda, Keertan Date: 2013 BACKGROUND: Treatment-related outcomes in patients with extensively drug-resistant tuberculosis (XDR-TB) are poor. However, data about the type, frequency and severity of presumed drug-associated adverse events (AEs) and their association ... Read more c b
Hyperglycaemic crisis in the Eastern Cape province of South Africa: High mortality and association of hyperosmolar ketoacidosis with a new diagnosis of diabetes

Author: Ekpebegh, C O ; Longo-Mbenza, B ; Akinrinmade, A ; Blanco-Blanco, E ; Badri, Motasim ; Levitt, N S Date: 2010 Objectives. To describe the frequencies, presenting characteristics (demographic, clinical and biochemical) and outcomes (duration of admission and mortality rates) for various types of hyperglycaemic crisis. Methods. Retrospective review of ... Read more
ICU-Associated Acinetobacter baumannii Colonisation/Infection in a High HIV-Prevalence Resource-Poor Setting

Author: Ntusi, Ntobeko B A ; Badri, Motasim ; Khalfey, Hoosain ; Whitelaw, Andrew ; Oliver, Stephen ; Piercy, Jenna ; Raine, Richard ; Joubert, Ivan ; Dheda, Keertan Date: 2012 BACKGROUND: There are hardly any data about the incidence, risk factors and outcomes of ICU-associated A.baumannii colonisation/infection in HIV-infected and uninfected persons from resource-poor settings like Africa. METHODS: We reviewed the ... Read more c b
Lack of association between stavudine exposure and lipoatrophy, dysglycaemia, hyperlactataemia and hypertriglyceridaemia: a prospective cross sectional study

Author: Sinxadi, Phumla ; van der Walt, Jan-Stefan ; McIlleron, Helen ; Badri, Motasim ; Smith, Peter ; Dave, Joel ; Levitt, Naomi ; Maartens, Gary Date: 2010 BACKGROUND: Stavudine continues to be widely used in resource poor settings despite its toxicity. Our objective was to determine association between plasma stavudine concentrations and lipoatrophy, concentrations of glucose, lactate and ... Read more c b
The mitochondrial DNA T16189C polymorphism and HIV-associated cardiomyopathy: a genotype-phenotype association study

Author: Shaboodien, Gasnat ; Engel, Mark E ; Syed, Faisal ; Poulton, Joanna ; Badri, Motasim ; Mayosi, Bongani Date: 2009 BACKGROUND: The mitochondrial DNA (mtDNA) T16189C polymorphism, with a homopolymeric C-tract of 10-12 cytosines, is a putative genetic risk factor for idiopathic dilated cardiomyopathy in the African and British populations. We hypothesized ... Read more c b
Performance of serum C-reactive protein as a screening test for smear-negative tuberculosis in an ambulatory high HIV prevalence population

Author: Wilson, Douglas ; Badri, Motasim ; Maartens, Gary Date: 2011 BACKGROUND: Delayed diagnosis has contributed to the high mortality of sputum smear-negative tuberculosis (SNTB) in high HIV prevalence countries. New diagnostic strategies for SNTB are urgently needed. C-reactive protein (CRP) is a non-specific ... Read more c b
Pregnancy-associated heart failure: a comparison of clinical presentation and outcome between hypertensive heart failure of pregnancy and idiopathic peripartum cardiomyopathy

Author: Ntusi, Ntobeko B A ; Badri, Motasim ; Gumedze, Freedom ; Sliwa, Karen ; Mayosi, Bongani M Date: 2015 AIMS: There is controversy regarding the inclusion of patients with hypertension among cases of peripartum cardiomyopathy (PPCM), as the practice has contributed significantly to the discrepancy in reported characteristics of PPCM. We sought ... Read more c b
Prevalence, hemodynamics, and cytokine profile of effusive-constrictive pericarditis in patients with tuberculous pericardial effusion

Author: Ntsekhe, Mpiko ; Matthews, Kerryn ; Syed, Faisal F ; Deffur, Armin ; Badri, Motasim ; Commerford, Patrick J ; Gersh, Bernard J ; Wilkinson, Katalin A ; Wilkinson, Robert J ; Mayosi, Bongani M Date: 2013 BACKGROUND: Effusive constrictive pericarditis (ECP) is visceral constriction in conjunction with compressive pericardial effusion. The prevalence of proven tuberculous ECP is unknown. Whilst ECP is distinguished from effusive disease on ... Read more c b
Risk factors for falls in older adults in a South African Urban Community

Author: Kalula, Sebastiana Zimba ; Ferreira, Monica ; Swingler, George H ; Badri, Motasim Date: 24 Feb 2016 Background: Studies on falls in older adults have mainly been conducted in high income countries. Scant, if any, information exists on risk factors for falls in the older population of sub-Saharan African countries. Methods: A cross-sectional ... Read more c b
A single-blinded trial of methotrexate versus azathioprine as steroid-sparing agents in generalized myasthenia gravis

Author: Heckmann, Jeannine ; Rawoot, Amanullah ; Bateman, Kathleen ; Renison, Rudi ; Badri, Motasim Date: 2011 BACKGROUND:Long-term immunosuppression is often required in myasthenia gravis (MG). There are no published trials using methotrexate (MTX) in MG. The steroid-sparing efficacy of azathioprine (AZA) has been demonstrated after 18-months of ... Read more c b
Stroke outcomes in a socio-economically disadvantaged urban community

Author: De Villiers, Linda ; Badri, Motasim ; Ferreira, Monica ; Bryer, Alan Date: 2011 AIMS: To determine survival, disability and functional outcomes of stroke patients following their discharge from an acute stroke unit in an urban community with limited rehabilitative resources. METHODS: Stroke patients were recruited from ... Read more
The burden and risk factors for adverse drug events in older patients - a prospective cross-sectional study

Author: Tipping, Brent ; Kalula, Sebastiana ; Badri, Motasim Date: 2006 Objective. To determine the burden and risk factors for adverse drug events (ADEs) in older patients. Design. A prospective cross-sectional study. Methods. Patients (65 years and older) presenting to the tertiary Emergency Unit of Groote ... Read more
Utility of CD4 cell counts for early prediction of virological failure during antiretroviral therapy in a resource-limited setting

Author: Badri, Motasim ; Lawn, Stephen D ; Wood, Robin Date: 2008 BACKGROUND:Viral load monitoring is not available for the vast majority of patients receiving antiretroviral therapy in resource-limited settings. However, the practical utility of CD4 cell count measurements as an alternative monitoring ... Read more c b
Utility of interferon-gamma ELISPOT assay responses in highly tuberculosis-exposed patients with advanced HIV infection in South Africa

Author: Lawn, Stephen ; Bangani, Nonzwakazi ; Vogt, Monica ; Bekker, Linda-Gail ; Badri, Motasim ; Ntobongwana, Marjorie ; Dockrell, Hazel ; Wilkinson, Robert ; Wood, Robin Date: 2007 BACKGROUND:Interferon-gamma (IFN-gamma) ELISPOT assays incorporating Mycobacterium tuberculosis-specific antigens are useful in the diagnosis of tuberculosis (TB) or latent infection. However, their utility in patients with advanced HIV is ... Read more c b

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Browsing by Author "Badri, Motasim"

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